PK-THPP
Chemical Name: 1-[1-[6-[[1,1'-Biphenyl]-4-ylcarbonyl)-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidin-4-yl]-4-piperidinyl]-1-butanone
Purity: ≥99%
Biological Activity
PK-THPP is a potent TASK-3 channel blocker (IC50 = 35 and 300 nM for TASK-3 and TASK-1 respectively). Increases breathing rate and induces respiratory alkalosis in rats.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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TASK-1 (KCNK3) and TASK-3 (KCNK9) tandem pore potassium channel antagonists stimulate breathing in isoflurane-anesthetized rats.
Cotten
Anesth.Analg., 2013;116:810 -
Discovery of a pharmacologically active antagonist of the two-pore-domain potassium channel K2P9.1 (TASK-3).
Coburn et al.
ChemMedChem, 2012;7:123
Product Datasheets
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Citation for PK-THPP
The citations listed below are publications that use Tocris products. Selected citations for PK-THPP include:
1 Citation: Showing 1 - 1
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Neurokinin-3 receptor activation selectively prolongs atrial refractoriness by inhibition of a background K+ channel.
Authors: Veldkamp Et al.
Nat Commun 2018;9:4357
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