PMPA (NAALADase inhibitor)

Biological Activity

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Background References

1. Inhibition of glutamate carboxypeptidase II (GCPII) activity as a treatment for cognitive impairment in multiple sclerosis.
   Rahn et al.
   Proc.Natl.Acad.Sci.U S A (Epub ahead of print], 2012;
2. Design, synthesis, and biological activity of a potent inhibitor of the neuropeptidase N-acetylated α-linked acidic dipeptidase.
   Jackson et al.
   J.Med.Chem., 1996;39:619
3. Selective inhibition of NAALADase, which converts NAAG to glutamate, reduces ischemic brain injury.
   Slusher et al.
   Nat.Med., 1999;5:1396
4. NAALADase inhibition protects motor neurons against chronic glutamate toxicity.
   Thomas et al.
   Eur.J.Pharmacol., 2003;471:177

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