PNU 120596

Key Product Details

Product Description

PNU 120596 is a positive allosteric modulator of α7 neuronal nicotinic acetylcholine receptors (EC₅₀ = 216 nM), with no detectable effect on α4β2, α3β4 and α9α10 receptors. Active in vivo following systemic administration. Neuroprotective in an in vivo model of transient focal cerebral ischemia.

Product Specifications for PNU 120596

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for PNU 120596

The following data is based on the product molecular weight 311.72.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.21 mL	16.04 mL	32.08 mL
5 mM	0.64 mL	3.21 mL	6.42 mL
10 mM	0.32 mL	1.60 mL	3.21 mL
50 mM	0.06 mL	0.32 mL	0.64 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 117 publications citing the usage of this product.

• Timmermann An allosteric modulator of the α7 nicotinic acetylcholine receptor possessing cognition-enhancing properties in vivo. J.Pharmacol.Exp.Ther. 2007 PMID: 17625074
• Kalappa A positive allosteric modulator of α7 nAChRs augments neuroprotective effects of endogenous nicotinic agonists in cerebral ischemia. Br.J.Pharmacol. [Epub ahead of print] 2013 PMID: 23713819
• Hurst A novel positive allosteric modulator of the α7 neuronal nicotinic acetylcholine receptor: in vitro and in vivo characterization. J.Neurosci. 2005 PMID: 15858066

Product Documents for PNU 120596