Home / Abl Kinase Inhibitors / PPY A

PPY A

Catalog #: 4730 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4730/10
4730/50
PPY A | CAS No. 875634-01-8 | Abl Kinase Inhibitors
1 Image
Description: Potent inhibitor of Abl T315l mutant and wild-type Abl kinases

Chemical Name: 5-[3-(2-Methoxyphenyl)-1H-pyrrolo[2,3-b]pyridin-5-yl]-N,N-dimethyl-3-pyridinecarboxamide

Purity: ≥98%

Product Details
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

PPY A is a potent inhibitor of T315l mutant and wild-type Abl kinases (IC50 values are 9 and 20 nM, respectively). Inhibits growth of cells transformed with either the Bcr-Abl T315l mutant or wild-type Bcr-Abl gene.

Technical Data

M.Wt:
372.42
Formula:
C22H20N4O2
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
875634-01-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Crystal structure of the T315I mutant of AbI kinase.
    Zhou et al.
    Chem.Biol.Drug.Des., 2007;70:171
  2. Inhibitors of ABL and the ABL-T315I mutation.
    Noronha et al.
    Curr.Top.Med.Chem., 2008;8:905

Product Datasheets

COA view current batch
Or select another batch:
View Batch
SDS
Reconstitution Calculator
Molarity Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

=
÷

Molarity Calculator

=
x
x
g/mol

*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for PPY A

There are currently no reviews for this product. Be the first to review PPY A and earn rewards!

Have you used PPY A?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review
Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.