(R)-DPN
Discontinued Product
Chemical Name: (R)-2,3-bis(4-Hydroxyphenyl)-propionitrile
Purity: ≥98%
Biological Activity
(R)-DPN is an enantiomer of DPN (Cat. No. 1494). Displays higher affinity for estrogen receptor (ER) β over ERα (Ki values are 1.82 and 147 nM respectively).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Estrogen receptor-β agonist diarylpropionitrile: biological activities of R- and S-enantiomers on behavior and hormonal response to stress.
Weiser et al.
Endocrinology, 2009;150:1817 -
Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands.
Carroll et al.
J.Med.Chem., 2011;55:528
Product Datasheets
Citation for (R)-DPN
The citations listed below are publications that use Tocris products. Selected citations for (R)-DPN include:
1 Citation: Showing 1 - 1
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Rat uterine oxyt. receptor and estrogen receptor α and β mRNA levels are regulated by estrogen through multiple estrogen receptors.
Authors: Murata Et al.
Mol Cell Biol 2014;60:55
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