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Recombinant Human IL-1 alpha/IL-1F1 Protein

Catalog #: 200-LA
65 Citations 8 Reviews Datasheet / COA / SDS

Carrier Free

Catalog # Availability Size / Price Qty
200-LA-002/CF
200-LA-010/CF

With Carrier

Catalog # Availability Size / Price Qty
200-LA-002
200-LA-010
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Recombinant Human IL-1 alpha/IL-1F1 Protein Bioactivity
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Product Details
Citations (65)
FAQs
Reviews (8)
Summary Product Datasheets Carrier Free Data Images Reconstitution Calculator Background Related Research Areas

Recombinant Human IL-1 alpha/IL-1F1 Protein Summary

Product Specifications

Purity
>97%, by SDS-PAGE under reducing conditions and visualized by silver stain
Endotoxin Level
<0.10 EU per 1 μg of the protein by the LAL method.
Activity
Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells. Symons, J.A. et al. (1987) in Lymphokines and Interferons, a Practical Approach. Clemens, M.J. et al. (eds): IRL Press. 272. The ED50 for this effect is 1‑6 pg/mL.
Source
E. coli-derived human IL-1 alpha/IL-1F1 protein
Ser113-Ala271
Accession #
Q53QF9
N-terminal Sequence
Analysis
Ser113
Predicted Molecular Mass
18 kDa

Product Datasheets

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200-LA (with carrier)

Product Datasheet
COA
SDS

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200-LA/CF (carrier free)

Product Datasheet
COA
SDS

Carrier Free

What does CF mean?

CF stands for Carrier Free (CF). We typically add Bovine Serum Albumin (BSA) as a carrier protein to our recombinant proteins. Adding a carrier protein enhances protein stability, increases shelf-life, and allows the recombinant protein to be stored at a more dilute concentration. The carrier free version does not contain BSA.

What formulation is right for me?

In general, we advise purchasing the recombinant protein with BSA for use in cell or tissue culture, or as an ELISA standard. In contrast, the carrier free protein is recommended for applications, in which the presence of BSA could interfere.

200-LA

Formulation Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Reconstitution Reconstitute at 10 μg/mL in sterile PBS containing at least 0.1% human or bovine serum albumin.
Shipping The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 3 months, -20 to -70 °C under sterile conditions after reconstitution.

200-LA/CF

Formulation Supplied as a 0.2 μm filtered solution in PBS.
Shipping The product is shipped with dry ice or equivalent. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage: Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after opening.

Scientific Data

Bioactivity Recombinant Human IL-1 alpha/IL-1F1 Protein Bioactivity View Larger

Recombinant Human IL-1 alpha /IL-1F1 (Catalog # 200-LA) stimulates cell proliferation of the D10.G4.1 mouse helper T cell line. The ED50 for this effect is 1-6 pg/mL.

SDS-PAGE Recombinant Human IL-1 alpha/IL-1F1 Protein SDS-PAGE View Larger

1 μg/lane of Recombinant Human IL-1 alpha /IL-1F1 was resolved with SDS-PAGE under reducing (R) conditions and visualized by silver staining, showing a single band at 18 kDa.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Background: IL-1 alpha/IL-1F1

Interleukin 1 (IL-1) is a name that designates two proteins, IL-1 alpha and IL-1 beta, which are the products of distinct genes, but which show approximately 25% amino acid sequence identity and which recognize the same cell surface receptors. Although IL-1 production is generally considered to be a consequence of inflammation, recent evidence suggests that IL-1 is also temporarily upregulated during bone formation and the menstrual cycle and can be induced in response to nervous system stimulation. In response to classic stimuli produced by inflammatory agents, infections or microbial endotoxins, a dramatic increase in the production of IL-1 by macrophages and various other cells is seen. Cells in particular known to produce IL-1 include osteoblasts, monocytes, macrophages, keratinocytes, Kupffer cells, hepatocytes, thymic and salivary gland epithelium, Schwann cells, fibroblasts and glia (oligodendroglia, astrocytes and microglia).

IL-1 alpha and IL-1 beta are both synthesized as 31 kDa precursors that are subsequently cleaved into proteins with molecular weights of approximately 17,000 Da. Neither precursor contains a typical hydrophobic signal peptide sequence and most of the precursor form of IL-1 alpha remains in the cytosol of cells, although there is evidence for a membrane-bound form of the precursor form of IL-1 alpha. The IL-1 alpha precursor reportedly shows full biological activity in the EL-4 assay. Among various species, the amino acid sequence of mature IL-1 alpha is conserved 60% to 70% and human IL-1 has been found to be biologically active on murine cell lines. Both forms of IL-1 bind to the same receptors, designated type I and type II. Evidence suggests that only the type I receptor is capable of signal transduction and that the type II receptor may function as a decoy, binding IL-1 and thus preventing binding of IL-1 to the type I receptor.

Long Name
Interleukin 1 alpha
Entrez Gene IDs
3552 (Human); 16175 (Mouse); 24493 (Rat); 397094 (Porcine); 101926546 (Cynomolgus Monkey)
Alternate Names
BAF; Hematopoietin-1; IL1 alpha; IL-1 alpha; IL1; IL1A; IL-1A; IL1-ALPHA; IL1F1; IL-1F1; IL1F1hematopoietin-1; interleukin 1, alpha; interleukin-1 alpha; LAF; LEM; preinterleukin 1 alpha; pro-interleukin-1-alpha

Citations for Recombinant Human IL-1 alpha/IL-1F1 Protein

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

65 Citations: Showing 1 - 10
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  1. Landscape of Interactions between Stromal and Myeloid Cells in Ileal Crohn's Disease; Indications of an Important Role for Fibroblast-Derived CCL-2
    Authors: Dovrolis, N;Valatas, V;Drygiannakis, I;Filidou, E;Spathakis, M;Kandilogiannakis, L;Tarapatzi, G;Arvanitidis, K;Bamias, G;Vradelis, S;Manolopoulos, VG;Paspaliaris, V;Kolios, G;
    Biomedicines
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  2. A keratinocyte-adipocyte signaling loop is reprogrammed by loss of BTG3 to augment skin carcinogenesis
    Authors: Cheng, YC;Acedera, JD;Li, YJ;Shieh, SY;
    Cell death and differentiation
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  3. Monitoring phosphorylation and acetylation of CRISPR-mediated HiBiT-tagged endogenous proteins
    Authors: Alves, J;Schwinn, M;Machleidt, T;Goueli, SA;Cali, JJ;Zegzouti, H;
    Scientific reports
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  4. Blockade of IL-6R prevents preterm birth and adverse neonatal outcomes
    Authors: Farias-Jofre, M;Romero, R;Galaz, J;Xu, Y;Miller, D;Garcia-Flores, V;Arenas-Hernandez, M;Winters, AD;Berkowitz, BA;Podolsky, RH;Shen, Y;Kanninen, T;Panaitescu, B;Glazier, CR;Pique-Regi, R;Theis, KR;Gomez-Lopez, N;
    EBioMedicine
    Species: Mouse
    Sample Types: In Vivo
    Applications: In Vivo
  5. Dietary Polyphenols Decrease Chemokine Release by Human Primary Astrocytes Responding to Pro-Inflammatory Cytokines
    Authors: Grabarczyk, M;Ksiazek-Winiarek, D;Glabinski, A;Szpakowski, P;
    Pharmaceutics
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  6. Crosstalk of protein clearance, inflammasome, and Ca2+ channels in retinal pigment epithelium derived from age-related macular degeneration patients
    Authors: Karema-Jokinen, V;Koskela, A;Hytti, M;Hongisto, H;Viheri�l�, T;Liukkonen, M;Torsti, T;Skottman, H;Kauppinen, A;Nymark, S;Kaarniranta, K;
    The Journal of biological chemistry
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  7. Human Primary Astrocytes Differently Respond to Pro- and Anti-Inflammatory Stimuli
    Authors: P Szpakowski, D Ksiazek-Wi, M Turniak-Ku, I Pacan, A Glabinski
    Biomedicines, 2022-07-22;10(8):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  8. Inflammasome Activation in Retinal Pigment Epithelium from Human Donors with Age-Related Macular Degeneration
    Authors: MC Ebeling, CR Fisher, RJ Kapphahn, MR Stahl, S Shen, J Qu, SR Montezuma, DA Ferrington
    Cells, 2022-06-30;11(13):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  9. Anti-Inflammatory and Anti-Fibrotic Effect of Immortalized Mesenchymal-Stem-Cell-Derived Conditioned Medium on Human Lung Myofibroblasts and Epithelial Cells
    Authors: E Filidou, L Kandilogia, G Tarapatzi, M Spathakis, P Steiropoul, D Mikroulis, K Arvanitidi, V Paspaliari, G Kolios
    International Journal of Molecular Sciences, 2022-04-20;23(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  10. Orally-active, clinically-translatable senolytics restore alpha-Klotho in mice and humans
    Authors: Y Zhu, LGPL Prata, EOW Gerdes, JME Netto, T Pirtskhala, N Giorgadze, U Tripathi, CL Inman, KO Johnson, A Xue, AK Palmer, T Chen, K Schaefer, JN Justice, AM Nambiar, N Musi, SB Kritchevsk, J Chen, S Khosla, D Jurk, MJ Schafer, T Tchkonia, JL Kirkland
    EBioMedicine, 2022-03-13;0(0):103912.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  11. The Activin/FLRG pathway associates with poor COVID-19 outcomes in hospitalized patients
    Authors: M McAleavy, Q Zhang, PJ Ehmann, J Xu, MF Wipperman, D Ajithdoss, L Pan, M Wakai, R Simonson, A Gadi, A Oyejide, SC Hamon, A Boyapati, LG Morton, T Shavlakadz, CA Kyratsous, DJ Glass
    Molecular and Cellular Biology, 2021-11-01;0(0):MCB0046721.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  12. ELTD1 Activation Induces an Endothelial-EMT Transition to a Myofibroblast Phenotype
    Authors: H Sheldon, J Alexander, E Bridges, L Moreira, S Reilly, KH Ang, D Wang, S Lin, S Haider, AH Banham, AL Harris
    International Journal of Molecular Sciences, 2021-10-19;22(20):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  13. Oncogene-induced senescence in hematopoietic progenitors features myeloid restricted hematopoiesis, chronic inflammation and histiocytosis
    Authors: R Biavasco, E Lettera, K Giannetti, D Gilioli, S Beretta, A Conti, S Scala, D Cesana, P Gallina, M Norelli, L Basso-Ricc, A Bondanza, G Cavalli, M Ponzoni, L Dagna, C Doglioni, A Aiuti, I Merelli, R Di Micco, E Montini
    Nature Communications, 2021-07-27;12(1):4559.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  14. Senolytics reduce coronavirus-related mortality in old mice
    Authors: Christina D. Camell, Matthew J. Yousefzadeh, Yi Zhu, Larissa G. P. Langhi Prata, Matthew A. Huggins, Mark Pierson et al.
    Science
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  15. Hydroquinone Induces NLRP3-Independent IL-18 Release from ARPE-19 Cells
    Authors: N Bhattarai, E Korhonen, Y Mysore, K Kaarnirant, A Kauppinen
    Cells, 2021-06-06;10(6):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  16. TAS-116, a Well-Tolerated Hsp90 Inhibitor, Prevents the Activation of the NLRP3 Inflammasome in Human Retinal Pigment Epithelial Cells
    Authors: S Ranta-Aho, N Piippo, E Korhonen, K Kaarnirant, M Hytti, A Kauppinen
    International Journal of Molecular Sciences, 2021-05-05;22(9):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  17. Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities
    Authors: M Hayn, M Hirschenbe, L Koepke, R Nchioua, JH Straub, S Klute, V Hunszinger, F Zech, C Prelli Boz, W Aftab, MH Christense, C Conzelmann, JA Müller, S Srinivasac, CM Stürzel, I Forne, S Stenger, KK Conzelmann, J Münch, FI Schmidt, D Sauter, A Imhof, F Kirchhoff, KMJ Sparrer
    Cell Reports, 2021-04-27;35(7):109126.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  18. Interleukin-1&alpha Is a Critical Mediator of the Response of Human Bronchial Fibroblasts to Eosinophilic Inflammation
    Authors: K Bernau, JP Leet, H Floerke, EM Bruhn, AL Noll, IS McDermott, S Esnault, NN Jarjour, N Sandbo
    Cells, 2021-03-02;10(3):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  19. 18F-FHBG PET-CT Reporter Gene Imaging of Adoptive CIK Cell Transfer Immunotherapy for Breast Cancer in a Mouse Model
    Authors: X Li, G Yin, W Ji, J Liu, Y Zhang, J Wang, X Zhu, L Zhu, D Dai, W Ma, W Xu
    Onco Targets Ther, 2020-11-13;13(0):11659-11668.
    Species: Human
    Sample Types: Whole Cells
    Applications: Cell Culture
  20. Soluble Compounds Released by Hypoxic Stroma Confer Invasive Properties to Pancreatic Ductal Adenocarcinoma
    Authors: D Liu, A Steins, R Klaassen, AP van der Za, RJ Bennink, G van Tienho, MG Besselink, MF Bijlsma, HWM van Laarho
    Biomedicines, 2020-10-22;8(11):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  21. The Pseudomonas aeruginosa protease LasB directly activates IL-1&beta
    Authors: J Sun, DL LaRock, EA Skowronski, JM Kimmey, J Olson, Z Jiang, AJ O'Donoghue, V Nizet, CN LaRock
    EBioMedicine, 2020-09-23;60(0):102984.
    Species: Mouse
    Sample Types: Reference Standard
  22. Systemic conditioned medium treatment from interleukin-1 primed mesenchymal stem cells promotes recovery after stroke
    Authors: CJ Cunningham, R Wong, J Barrington, S Tamburrano, E Pinteaux, SM Allan
    Stem Cell Res Ther, 2020-01-21;11(1):32.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  23. PASylation of IL-1 Receptor antagonist (IL-1Ra) retains IL-1 blockade and extends its duration in mouse urate crystal-induced peritonitis
    Authors: NE Powers, B Swartzwelt, C Marchetti, DM de Graaf, A Lerchner, M Schlapschy, R Datar, U Binder, CK Edwards, A Skerra, CA Dinarello
    J. Biol. Chem., 2019-12-09;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  24. Oxidative Stress is the Principal Contributor to Inflammasome Activation in Retinal Pigment Epithelium Cells with Defunct Proteasomes and Autophagy
    Authors: N Piippo, E Korhonen, M Hytti, K Kinnunen, K Kaarnirant, A Kauppinen
    Cell. Physiol. Biochem., 2018-08-23;49(1):359-367.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  25. Chemoproteomics of matrix metalloproteases in a model of cartilage degeneration suggests functional biomarkers associated with posttraumatic osteoarthritis
    Authors: KC Ravindra, CC Ahrens, Y Wang, JY Ramseier, JS Wishnok, LG Griffith, AJ Grodzinsky, SR Tannenbaum
    J. Biol. Chem., 2018-05-23;0(0):.
    Species: Bovine
    Sample Types: Whole Tissue
    Applications: Bioassay
  26. Interleukin-17A-induced production of acute serum amyloid A by keratinocytes contributes to psoriasis pathogenesis
    Authors: E Couderc, F Morel, P Levillain, A Buffière-M, M Camus, C Paquier, C Bodet, JF Jégou, M Pohin, L Favot, M Garcia, V Huguier, J Mcheik, C Lacombe, H Yssel, G Guillet, FX Bernard, JC Lecron
    PLoS ONE, 2017-07-14;12(7):e0181486.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  27. Prevalence and correlation of cytokine-specific autoantibodies with epidemiological factors and C-reactive protein in 8,972 healthy individuals: Results from the Danish Blood Donor Study
    Authors: JH von Steman, AS Rigas, LW Thørner, DGK Rasmussen, OB Pedersen, K Rostgaard, C Erikstrup, H Ullum, MB Hansen
    PLoS ONE, 2017-06-30;12(6):e0179981.
    Species: Human
    Sample Types: Plasma
    Applications: Control
  28. Atorvastatin Promotes Phagocytosis and Attenuates Pro-Inflammatory Response in Human Retinal Pigment Epithelial Cells
    Authors: B Tian, A Al-Moujahe, P Bouzika, Y Hu, S Notomi, P Tsoka, JW Miller, H Lin, DG Vavvas
    Sci Rep, 2017-05-24;7(1):2329.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  29. Interleukin-1 primes human mesenchymal stem cells towards an anti-inflammatory and pro-trophic phenotype in vitro
    Authors: E Redondo-Ca, C Cunningham, J Miller, L Martuscell, S Aoulad-Ali, NJ Rothwell, CM Kielty, SM Allan, E Pinteaux
    Stem Cell Res Ther, 2017-04-17;8(1):79.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  30. Apigenin suppresses the senescence-associated secretory phenotype and paracrine effects on breast cancer cells
    Authors: KM Perrott, CD Wiley, PY Desprez, J Campisi
    Geroscience, 2017-04-04;39(2):161-173.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  31. Inflammatory hypoxia induces syndecan-2 expression through IL-1?-mediated FOXO3a activation in colonic epithelia
    Authors: Sojoong Choi
    FASEB J, 2016-12-28;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  32. Inflammatory Adipokines Decrease Expression of Two High Molecular Weight Isoforms of Tropomyosin Similar to the Change in Type 2 Diabetic Patients
    PLoS ONE, 2016-09-20;11(9):e0162908.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  33. Smooth Muscle Enriched Long Non-Coding RNA (SMILR) Regulates Cell Proliferation
    Authors: MD Ballantyne, K Pinel, R Dakin, AT Vesey, L Diver, R Mackenzie, R Garcia, P Welsh, N Sattar, G Hamilton, N Joshi, MR Dweck, JM Miano, MW McBride, DE Newby, RA McDonald, AH Baker
    Circulation, 2016-04-06;0(0):.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  34. Characterization of the MMP/TIMP Imbalance and Collagen Production Induced by IL-1? or TNF-? Release from Human Hepatic Stellate Cells
    Authors: S Robert, T Gicquel, A Bodin, V Lagente, E Boichot
    PLoS ONE, 2016-04-05;11(4):e0153118.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  35. Myostatin is a direct regulator of osteoclast differentiation and its inhibition reduces inflammatory joint destruction in mice.
    Authors: Dankbar B, Fennen M, Brunert D, Hayer S, Frank S, Wehmeyer C, Beckmann D, Paruzel P, Bertrand J, Redlich K, Koers-Wunrau C, Stratis A, Korb-Pap A, Pap T
    Nat Med, 2015-08-03;21(9):1085-90.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  36. Brief Glutamine Pretreatment Increases Alveolar Macrophage CD163/Heme Oxygenase-1/p38-MAPK Dephosphorylation Pathway and Decreases Capillary Damage but Not Neutrophil Recruitment in IL-1/LPS-Insufflated Rats.
    Authors: Fernandez-Bustamante A, Agazio A, Wilson P, Elkins N, Domaleski L, He Q, Baer K, Moss A, Wischmeyer P, Repine J
    PLoS ONE, 2015-07-06;10(7):e0130764.
    Species: Rat
    Sample Types: In Vivo
    Applications: In Vivo
  37. MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
    Authors: Laberge R, Sun Y, Orjalo A, Patil C, Freund A, Zhou L, Curran S, Davalos A, Wilson-Edell K, Liu S, Limbad C, Demaria M, Li P, Hubbard G, Ikeno Y, Javors M, Desprez P, Benz C, Kapahi P, Nelson P, Campisi J
    Nat Cell Biol, 2015-07-06;17(8):1049-61.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  38. Inhibition of keratinocyte differentiation by the synergistic effect of IL-17A, IL-22, IL-1alpha, TNFalpha and oncostatin M.
    Authors: Rabeony H, Petit-Paris I, Garnier J, Barrault C, Pedretti N, Guilloteau K, Jegou J, Guillet G, Huguier V, Lecron J, Bernard F, Morel F
    PLoS ONE, 2014-07-10;9(7):e101937.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  39. Fetal human keratinocytes produce large amounts of antimicrobial peptides: involvement of histone-methylation processes.
    Authors: Gschwandtner M, Zhong S, Tschachler A, Mlitz V, Karner S, Elbe-Burger A, Mildner M
    J Invest Dermatol, 2014-04-02;134(8):2192-201.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  40. Proinflammatory stimuli induce galectin-9 in human mesenchymal stromal cells to suppress T-cell proliferation.
    Authors: Gieseke F, Kruchen A, Tzaribachev N, Bentzien F, Dominici M, Muller I
    Eur J Immunol, 2013-07-23;43(10):2741-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  41. Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
    Authors: Wilson TR, Fridlyand J, Yan Y, Penuel E, Burton L, Chan E, Peng J, Lin E, Wang Y, Sosman J, Ribas A, Li J, Moffat J, Sutherlin DP, Koeppen H, Merchant M, Neve R, Settleman J
    Nature, 2012-07-26;487(7408):505-9.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  42. Interleukin-1alpha controls allergic sensitization to inhaled house dust mite via the epithelial release of GM-CSF and IL-33.
    J. Exp. Med., 2012-07-16;209(8):1505-17.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  43. Tumor-stromal crosstalk in invasion of oral squamous cell carcinoma: a pivotal role of CCL7.
    Authors: Jung DW, Che ZM, Kim J, Kim K, Kim KY, Williams D, Kim J
    Int. J. Cancer, 2010-07-15;127(2):332-44.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  44. Evidence for altered Wnt signaling in psoriatic skin.
    Authors: Gudjonsson JE, Johnston A, Stoll SW
    J. Invest. Dermatol., 2010-04-08;130(7):1849-59.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  45. Skin Inflammation Induced by the Synergistic Action of IL-17A, IL-22, Oncostatin M, IL-1alpha, and TNF-alpha Recapitulates Some Features of Psoriasis.
    Authors: Guilloteau K, Paris I, Pedretti N, Boniface K, Juchaux F, Huguier V, Guillet G, Bernard FX, Lecron JC, Morel F
    J. Immunol., 2010-03-24;184(0):5263-70.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  46. Development and validation of sandwich ELISA microarrays with minimal assay interference.
    Authors: Gonzalez RM, Seurynck-Servoss SL, Crowley SA
    J. Proteome Res., 2008-04-19;7(6):2406-14.
    Applications: ELISA (Standard)
  47. Upregulation of human cytomegalovirus by HIV type 1 in human lymphoid tissue ex vivo.
    Authors: Biancotto A, Iglehart SJ, Lisco A, Vanpouille C, Grivel JC, Lurain NS, Reichelderfer PS, Margolis LB
    AIDS Res. Hum. Retroviruses, 2008-03-01;24(3):453-62.
    Applications: ELISA (Standard)
  48. Effect of serum content and diluent selection on assay sensitivity and signal intensity in multiplex bead-based immunoassays.
    Authors: Pfleger C, Schloot N, ter Veld F
    J. Immunol. Methods, 2007-10-22;329(1):214-8.
    Applications: ELISA (Standard)
  49. Ultrasensitive flow-based immunoassays using single-molecule counting.
    Authors: Todd J, Freese B, Lu A, Held D, Morey J, Livingston R, Goix P
    Clin. Chem., 2007-09-21;53(11):1990-5.
    Applications: ELISA (Standard)
  50. Synergism of TNF and IL-1 in the induction of matrix metalloproteinase-3 in trabecular meshwork.
    Authors: Kelley MJ, Rose AY, Song K, Chen Y, Bradley JM, Rookhuizen D, Acott TS
    Invest. Ophthalmol. Vis. Sci., 2007-06-01;48(6):2634-43.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  51. P2X receptor characterization and IL-1/IL-1Ra release from human endothelial cells.
    Authors: Wilson HL, Varcoe RW, Stokes L, Holland KL, Francis SE, Dower SK, Surprenant A, Crossman DC
    Br. J. Pharmacol., 2007-03-12;151(1):115-27.
    Applications: Western Blot
  52. Bradykinin potentiates cytokine-induced prostaglandin biosynthesis in osteoblasts by enhanced expression of cyclooxygenase 2, resulting in increased RANKL expression.
    Authors: Brechter AB, Lerner UH
    Arthritis Rheum., 2007-03-01;56(3):910-23.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  53. Abnormal activation and cytokine spectra in lymph nodes of people chronically infected with HIV-1.
    Authors: Biancotto A, Grivel JC, Iglehart SJ, Vanpouille C, Lisco A, Sieg SF, Debernardo R, Garate K, Rodriguez B, Margolis LB, Lederman MM
    Blood, 2007-02-08;109(10):4272-9.
    Applications: ELISA (Standard)
  54. IL-10 inhibits endothelium-dependent T cell costimulation by up-regulation of ILT3/4 in human vascular endothelial cells.
    Authors: Gleissner CA, Zastrow A, Klingenberg R, Kluger MS, Konstandin M, Celik S, Haemmerling S, Shankar V, Giese T, Katus HA, Dengler TJ
    Eur. J. Immunol., 2007-01-01;37(1):177-92.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  55. An inflammation-induced mechanism for leukocyte transmigration across lymphatic vessel endothelium.
    Authors: Johnson LA, Clasper S, Holt AP, Lalor PF, Baban D, Jackson DG
    J. Exp. Med., 2006-11-20;203(12):2763-77.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  56. L5, the most electronegative subfraction of plasma LDL, induces endothelial vascular cell adhesion molecule 1 and CXC chemokines, which mediate mononuclear leukocyte adhesion.
    Authors: Abe Y, Fornage M, Yang CY, Bui-Thanh NA, Wise V, Chen HH, Rangaraj G, Ballantyne CM
    Atherosclerosis, 2006-10-04;192(1):56-66.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  57. Transforming growth factor-alpha: a major human serum factor that promotes human keratinocyte migration.
    Authors: Li Y, Fan J, Chen M, Li W, Woodley DT
    J. Invest. Dermatol., 2006-05-11;126(9):2096-105.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  58. Pre-interleukin-1alpha expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1).
    Authors: Palmer G, Trolliet S, Talabot-Ayer D, Mezin F, Magne D, Gabay C
    Cytokine, 2005-07-21;31(2):153-60.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  59. CYP7B expression and activity in fibroblast-like synoviocytes from patients with rheumatoid arthritis: regulation by proinflammatory cytokines.
    Authors: Dulos J, van der Vleuten MA, Kavelaars A, Heijnen CJ, Boots AM
    Arthritis Rheum., 2005-03-01;52(3):770-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  60. IL-17 markedly up-regulates beta-defensin-2 expression in human airway epithelium via JAK and NF-kappaB signaling pathways.
    Authors: Kao CY, Chen Y, Thai P, Wachi S, Huang F, Kim C, Harper RW, Wu R
    J. Immunol., 2004-09-01;173(5):3482-91.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  61. Interleukin-1 inhibits voltage-dependent P/Q-type Ca2+ channel associated with the inhibition of the rise of intracellular free Ca2+ concentration and catecholamine release in adrenal chromaffin cells.
    Authors: Morita K, Miyasako T, Kitayama S, Dohi T
    Biochim. Biophys. Acta, 2004-08-04;1673(3):160-9.
    Species: Bovine
    Sample Types: Whole Cells
    Applications: Bioassay
  62. The effect of inflammatory cytokines on secretion of macrophage colony-stimulating factor and monocyte chemoattractant protein-1 in human granulosa cells.
    Authors: Kawano Y, Fukuda J, Itoh H, Takai N, Nasu K, Miyakawa I
    Am. J. Reprod. Immunol., 2004-08-01;52(2):124-8.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  63. The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action.
    Authors: Smith DE, Hanna R, Della Friend, Moore H, Chen H, Farese AM, MacVittie TJ, Virca GD, Sims JE
    Immunity, 2003-01-01;18(1):87-96.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  64. c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin.
    Authors: Szabowski A, Maas-Szabowski N, Andrecht S, Kolbus A, Schorpp-Kistner M, Fusenig NE, Angel P
    Cell, 2000-11-22;103(5):745-55.
    Species: Human
    Sample Types: Whole Cells
    Applications: Bioassay
  65. Gingival crevicular fluid from patients with periodontitis contains bone resorbing activity.
    Authors: Lerner UH, Modeer T, Krekmanova L, Claesson R, Rasmussen L
    Eur. J. Oral Sci., 1998-06-01;106(3):778-87.
    Species: Mouse
    Sample Types: Whole Cells
    Applications: Bioassay

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Average Rating: 4.9 (Based on 8 Reviews)

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Recombinant Human IL-1 alpha/IL-1F1 Protein
By Anonymous on 09/16/2021
Application: In vitro bioactivity in cell culture
Recombinant Human IL-1 alpha/IL-1F1 Protein
By Anonymous on 04/13/2021
Application: In vitro bioactivity in cell culture
Recombinant Human IL-1 alpha/IL-1F1 Protein
By Anonymous on 12/22/2020
Application: In vitro bioactivity in cell culture
In vitro bioactivity in cell culture Recombinant Human IL-1 alpha/IL-1F1 Protein 200-LA
Recombinant Human IL-1 alpha/IL-1F1 Protein
By Anonymous on 06/04/2019
Application: Cell migration/motility
Recombinant Human IL-1 alpha/IL-1F1 Protein
By Joseph Moore on 05/14/2019
Application: In vitro bioactivity in cell culture
Reason for Rating: We used this in chondral explants as a positive control for osteoarthritis. It increases activity of comp, MMP13, and many other marks for OA. This is our labs staple IL and it works prefect every time.
In vitro bioactivity in cell culture Recombinant Human IL-1 alpha/IL-1F1 Protein 200-LA
Recombinant Human IL-1 alpha/IL-1F1 Protein
By Anonymous on 01/30/2019
Application: Cell migration/motility
Recombinant Human IL-1 alpha/IL-1F1 Protein
By Anonymous on 11/01/2018
Application: Cell migration/motility
Recombinant Human IL-1 alpha/IL-1F1 Protein
By Anonymous on 03/30/2018
Application: In vitro bioactivity in cell culture