Rivastigmine tartrate

Key Product Details

Product Description

Rivastigmine tartrate is a cholinesterase inhibitor; inhibits both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) (IC₅₀ ranges are 4.3-4760 nM and 16-238 nM respectively). Rivastigmine increases α-secretase activity and directs APP processing to the non-amyloidogenic pathway. Brain penetrant.

Product Specifications for Rivastigmine tartrate

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for Rivastigmine tartrate

The following data is based on the product molecular weight 400.42.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.50 mL	12.49 mL	24.97 mL
5 mM	0.50 mL	2.50 mL	4.99 mL
10 mM	0.25 mL	1.25 mL	2.50 mL
50 mM	0.05 mL	0.25 mL	0.50 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Brus J.Med.Chem.
• Bailey Rivastigmine lowers Aβ and increases sAPPα levels, which parallel elevated synaptic markers and metabolic activity in degenerating primary rat neurons. PLoS One 2011 PMID: 21799757
• Luo Inhibition of human acetyl- and butyrylcholinesterase by novel carbamates of (-)- and (+)-tetrahydrofurobenzofuran and methanobenzodioxepine. J.Med.Chem. 2006 PMID: 16570913
• Mehta New acetylcholinesterase inhibitors for Alzheimer's disease. Int.J.Alzheimers Dis 2012 PMID: 22216416
• Groner The kinetics of inhibition of human acetylcholinesterase and butyrylcholinesterase by two series of novel carbamates. Mol.Pharmacol. 2007 PMID: 17347320

Product Documents for Rivastigmine tartrate