RS 39604 hydrochloride

Key Product Details

Product Description

RS 39604 hydrochloride is a potent and selective 5-HT₄ antagonist, with a pK_i of 9.1 at 5-HT₄ receptors in guinea pig striatal membranes and greater than 1000-fold selectivity over 5-HT_{1A, 2C, 3} and D₁, D₂, M₁, M₂, AT_1, B₁ and α_1C receptors. The ketone group gives RS 39604 a relatively long half life; it is also orally active and so suitable for in vivo studies.

Licensing Information

Sold with the permission of Roche Bioscience

Product Specifications for RS 39604 hydrochloride

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for RS 39604 hydrochloride

The following data is based on the product molecular weight 590.56.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	1.69 mL	8.47 mL	16.93 mL
5 mM	0.34 mL	1.69 mL	3.39 mL
10 mM	0.17 mL	0.85 mL	1.69 mL
50 mM	0.03 mL	0.17 mL	0.34 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 10 publications citing the usage of this product.

• Hegde RS 39604: a potent, selective and orally active 5-HT₄ receptor antagonist. Br.J.Pharmacol. 1995 PMID: 7582507
• Eglen Central 5-HT₄ receptors TiPS 1995 PMID: 8578609

Product Documents for RS 39604 hydrochloride