Rupintrivir
Chemical Name: Ethyl (2E,4S)-4-[[(2R,5S)-2-[(4-fluorophenyl)methyl]-6-methyl-5-[[(5-methyl-3-isoxazolyl)carbonyl]amino]-1,4-dioxoheptyl]amino]-5-[(3S)-2-oxo-3-pyrrolidinyl]-2-pentenoate
Purity: ≥98%
Biological Activity
Rupintrivir is a potent and selective irreversible human rhinovirus (HRV) 3C protease inhibitor (EC50 = 5 nM). Exhibits no significant inhibition against a variety of serine and cysteine proteases. Inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays.Tocris products are for biomedical research use only. They are not intended for human or veterinary use.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
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Additional Information
Background References
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In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease.
Patick et al.
Antimicrob.Agents Chemother., 1999;43:2444 -
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics.
Dragovich et al.
J.Med.Chem., 1999;42:1203
Product Datasheets
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