SB 334867

Key Product Details

Product Description

SB 334867 is a selective non-peptide orexin OX₁ receptor antagonist. pK_b values are 7.2 and < 5 for inhibition of intracellular Ca²⁺ release in CHO cells expressing human OX₁ and OX₂ receptors respectively. Blocks orexin-A induced grooming and feeding following systemic administration in vivo.

Licensing Information

Sold for research purposes under agreement from GlaxoSmithKline

Product Specifications for SB 334867

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for SB 334867

The following data is based on the product molecular weight 319.32.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

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Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	3.13 mL	15.66 mL	31.32 mL
5 mM	0.63 mL	3.13 mL	6.26 mL
10 mM	0.31 mL	1.57 mL	3.13 mL
50 mM	0.06 mL	0.31 mL	0.63 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 246 publications citing the usage of this product.

• Smart SB-334867-A: the first selective orexin-1 receptor antagonist. Br.J.Pharmacol. 2001 PMID: 11250867
• Haynes A selective orexin-1 receptor antagonist reduces food consumption in male and female rats. Regul.Pept. 2000 PMID: 11102651
• Porter 1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor. Bioorg.Med.Chem.Lett. 2001 PMID: 11459658
• Duxon Evidence that orexin-A-evoked grooming in the rat is mediated by orexin-1 (OX₁) receptors, with downstream 5-HT_2C receptor involvement. Psychopharmacology 2001 PMID: 11205420

Product Documents for SB 334867