SJFδ
Chemical Name: N-(3-Fluoro-4-((7-(2-(2-(2-(2-(((2S,4R)-4-hydroxy-1-((S)-3-methyl-2-(1-oxoisoindolin-2-yl)butanoyl)pyrrolidine-2-carboxamido)methyl)-5-(4-methylthiazol-5-yl)phenoxy)ethoxy)ethoxy)ethoxy)-6-methoxyquinolin-4-yl)oxy)phenyl)-N-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide
Purity: ≥98%
Biological Activity
SJFδ is a potent and selective PROTAC ® Degrader of p38δ (DC50 = 46.17 nM; Dmax = 99.41%). SJFδ comprises the multikinase inhibitor foretinib joined by a linker to a VHL ligand. Exhibits no significant degradation of p38α, β or γ. Selectively degrades p38δ in MDA-MB-231 cells.PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Differential PROTAC substrate specificity dictated by orientation of recruited E3 ligase.
Smith et al.
Nat.Commun., 2019;10:131
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