(+)-SK&F 10047 hydrochloride
Chemical Name: (2S,6S,11S)-1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-(2-propenyl)-2,6-methano-3-benzazocin-8-ol hydrochloride
Purity: ≥98%
Biological Activity
(+)-SK&F 10047 hydrochloride is a prototypical σ1 receptor agonist. Behaviorally active in animal models of memory and stress.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death.
Fox JT, Sakamuru S, Huang R
Proc. Natl. Acad. Sci. U.S.A., 2012;109(14):5423-8. -
(+)-SKF-10,047 and dextromethorphan ameliorate conditioned fear stress via DArgic systems linked to phenytoin-regulated σ1 sites.
Kamei et al.
Eur.J.Pharmacol., 1996;309:149 -
Involvement of σ1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats.
Matsuno et al.
Brain Res., 1995;690:200 -
Sigma receptors: biology and function.
Walker et al.
Pharmacol.Rev., 1990;42:355
Product Datasheets
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Citations for (+)-SK&F 10047 hydrochloride
The citations listed below are publications that use Tocris products. Selected citations for (+)-SK&F 10047 hydrochloride include:
5 Citations: Showing 1 - 5
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Choline Is an Intracellular Messenger Linking Extracellular Stimuli to IP3-Evoked Ca2+ Signals through Sigma-1 Receptors.
Authors: Brailoiu Et al.
Cell Rep 2019;26:330
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The σ1 receptor regulates accumulation of GM1 ganglioside-enriched autophagosomes in astrocytes
Authors: Kasaharaa Et al.
Neuroscience 2016;340:176
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The ON:OFF switch, σ1R-HINT1 protein, controls GPCR-NMDA receptor cross-regulation: implications in neurological disorders.
Authors: Rodríguez-Muñoz Et al.
Int J Neuropsychopharmacol 2015;6:35458
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The calcium-sensitive σ-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
Authors: Sánchez-Blázquez Et al.
PLoS One 2014;17:1943
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Inhibition of endothelial cell Ca2+ entry and transient receptor potential channels by Sigma-1 receptor ligands.
Authors: Amer Et al.
Br J Pharmacol 2013;168:1445
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