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SMER 3

Catalog #: 4375
1 Citation Datasheet / COA / SDS
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4375/10
SMER 3 | CAS No. 67200-34-4 | Ubiquitin Ligase (E3) Inhibitors
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Description: Selective inhibitor of E3 ubiquitin ligase

Chemical Name: 9H-Indeno[1,2-e][1,2,5]oxadiazolo[3,4-b]pyrazin-9-one

Purity: ≥98%

Product Details
Citations (1)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

SMER 3 is a selective inhibitor of a yeast SCF family E3 ubiquitin ligase (SCFMet30) in vitro and in vivo. Induces the expression of MET genes; blocks cell proliferation. Enhancer of rapamycin (Cat. No. 1292).

Technical Data

M.Wt:
224.18
Formula:
C11H4N4O2
Solubility:
Soluble to 75 mM in DMSO
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
67200-34-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads
    J Jain, SK Jain, LA Walker, BL Tekwani
    BMC Pharmacol Toxicol, 2017;18(1):40.
  2. Chemical genetics of TOR identifies an SCF family E3 ubiquitin ligase inhibitor.
    Aghajanyy et al.
    Nat.Biotechnol., 2010;28:738

Product Datasheets

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Citation for SMER 3

The citations listed below are publications that use Tocris products. Selected citations for SMER 3 include:

1 Citation: Showing 1 - 1

  1. Inhibitors of ubiquitin E3 ligase as potential new antimalarial drug leads.
    Authors: Babu L Et al.
    BMC Pharmacol Toxicol  2017;18:40

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