Spermine NONOate

Name: Spermine NONOate
Brand: Tocris Bioscience
SKU: 1135

Catalog #: 1135
1 Citation Datasheet / COA / SDS

Discontinued Product

1135 has been discontinued.

View all Nitric Oxide Donor/Precursor Compounds products.

Spermine NONOate | CAS No. 136587-13-8 | Nitric Oxide Donor/Precursor Compounds

1 Image

Description: Slow NO releasing agent

Chemical Name: N-[4-[1-(3-Aminopropyl)-2-hydroxy-2-nitrosohydrazino]butyl-1,3-propanediamine

View All Products for Nitric Oxide Donor/Precursor Compounds

Product Details

Citations (1)

Reviews

Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

A stable complex of nitric oxide and spermine used to generate a controlled release of nitric oxide in solution (EC₅₀ = 6.2 μM for relaxation of rabbit aorta, and t_½ =39 min at 37°C, pH 7.4, aqueous solution).

Technical Data

M.Wt:

262.35

Formula:

C₁₀H₂₆N₆O₂

Solubility:

Soluble to 100 mM in water

Storage:

Desiccate at -20°C

CAS No:

136587-13-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:

Sold with the permission of the NIH, US Patent 5,155,137

Background References

Comparative effects of several nitric oxide donors on intracellular cyclic GMP levels in bovine chromaffin cells: correlation with nitric oxide production.
Ferrero et al.
Br.J.Pharmacol., 1999;127:779
In vitro comparison of two NONOates (novel nitric oxide donors) on rat pulmonary arteries.
Homer and Wanstall
Eur.J.Pharmacol., 1998;356:49
Complexes of NO with nucleophiles as agents for the controlled biological release of nitric oxide. Vasorelaxant effects.
Maragos et al.
J.Med.Chem., 1991;34:3242
Measurement and modeling of nitric oxide release rates for nitric oxide donors.
Ramamurthi and Lewis
Chem.Res.Toxicol., 1997;10:408

Product Datasheets

COA view current batch

Or select another batch:

View Batch

SDS

Reconstitution Calculator

Molarity Calculator

Citation for Spermine NONOate

The citations listed below are publications that use Tocris products. Selected citations for Spermine NONOate include:

1 Citation: Showing 1 - 1

Modulation of ligand-heme reactivity by binding pocket residues demonstrated in cytochrome c' over the femtosecond-second temporal range.
Authors: Russell Et al.
FEBS J 2013;280:6070

FAQs

No product specific FAQs exist for this product, however you may

View all Small Molecule FAQs

Reviews for Spermine NONOate

There are currently no reviews for this product. Be the first to review Spermine NONOate and earn rewards!

Have you used Spermine NONOate?

Submit a review and receive an Amazon gift card.

$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image

$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image

Submit a Review

Tocris Bioscience is the leading supplier of novel and exclusive tools for life science research with over 30 years' experience in the industry. Tocris is a Bio-Techne brand.