StemRegenin 1

Biological Activity

StemReginin 1 is an aryl hydrocarbon receptor (AHR) antagonist (IC₅₀ = 127 nM). StemReginin 1 exhibits no inhibitory activity against a panel of 61 kinases and preferentially inhibits human AHR. StemReginin 1 promotes the expansion of CD34+ cells ex vivo. In hematopoietic stem cell (HSC) culture, the compound induces a 50-fold increase in CD34-expressing cells, and HSCs cultured with StemReginin 1 show increased engraftment in mice. Combination of StemReginin 1 with DMOG (Cat. No. 4408) increases the proportion of primitive HSCs and improves long-term engraftment. The product also promotes expansion of human promyelocytic leukemia cell line NB4.

Technical Data

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

1. Targeting the aryl hydrocarbon receptor nuclear translocator complex with DMOG and Stemregenin 1 improves primitive hematopoietic stem cell expansion.
   Jackson CS, Durandt C, Janse van Rensburg I et al.
   Stem Cell Res.
2. Aryl hydrocarbon receptor antagonists promote the expansion of human hematopoietic stem cells.
   Boitano et al.
   Science, 2010;329:1345

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