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TAK 779

Catalog #: 4340 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
4340/10
4340/50
TAK 779 | CAS No. 229005-80-5 | Chemokine Receptor Antagonists
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Description: Potent and selective CCR5 and CCR2 chemokine receptor antagonist

Chemical Name: N-[[4-[[[6,7-Dihydro-2-(4-methylphenyl)-5H-benzocyclohepten-8-yl]carbonyl]amino]phenyl]methyl]tetrahydro-N,N-dimethyl-2H-pyran-4-aminium chloride

Purity: ≥98%

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Biological Activity

TAK 779 is a potent and selective CCR5 and CCR2 chemokine receptor antagonist (IC50 values = 1 nM and 27 nM, respectively). TAK 779 blocks the binding of macrophage inflammatory protein 1α and 1β to CHO cells (IC50 = 1 nM) and inhibits replication of R5 HIV-1 at 1.6-3.7 nM. In animal models, TAK 779 protects against ischemic brain injury and prevents development of asthma features.

Technical Data

M.Wt:
531.13
Formula:
C33H39N2O2.Cl
Solubility:
Soluble to 10 mM in water and to 5 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
229005-80-5

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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