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TC KHNS 11

Catalog #: 6079 Datasheet / COA / SDS

Discontinued Product

6079 has been discontinued.
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TC KHNS 11 | CAS No. 1431540-99-6 | PI 3-Kinase Inhibitors
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Description: Potent and selective PI 3-kinase δ inhibitor; orally bioavailable

Chemical Name: 5-[4-[3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-2-methoxy-3-pyridinecarbonitrile

Purity: ≥98%

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Biological Activity

TC KHNS 11 is a potent and selective PI 3-kinase δ inhibitor (biochemical IC50 values are 9, 262, 1650 and 4630 nM for PI 3-Kδ, PI 3-Kα, PI 3-Kβ and PI 3-Kγ, respectively; cellular IC50 values are 49, 3440 and 6530 nM for PI 3-Kδ, PI 3-Kα and PI 3-Kβ, respectively). Selective for PI 3-Kδ over a panel of lipid and protein kinases. Inhibits B-cell function. Exhibits moderate oral bioavailability in vivo.

Technical Data

M.Wt:
492.53
Formula:
C28H24N6O3
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1431540-99-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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