TCS JNK 6o

Key Product Details

Product Description

TCS JNK 6o is an ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor (IC₅₀ values are 2, 4 and 52 nM for JNK1, JNK2 and JNK3 respectively). Displays > 1000 fold selectivity over other kinases, including ERK2 and p38. Inhibits c-Jun phosphorylation (EC₅₀ = 920 nM) and prevents collagen-induced platelet aggregation in vitro.

TCS JNK 6o synthesized to Ancillary Material Grade also available.

Product Specifications for TCS JNK 6o

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Solubility

Preparing Stock Solutions for TCS JNK 6o

The following data is based on the product molecular weight 356.38.

Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which all affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:

8 7 6 5 4 3 2 1 Recalculate

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
1 mM	2.81 mL	14.03 mL	28.06 mL
5 mM	0.56 mL	2.81 mL	5.61 mL
10 mM	0.28 mL	1.40 mL	2.81 mL
50 mM	0.06 mL	0.28 mL	0.56 mL

Calculators

Background References

References are publications that support the biological activity of the product. See our Citations tab to view 19 publications citing the usage of this product.

• Kauskot Involvement of the mirogen-activated protein kinase c-Jun NH₂-terminal kinase 1 in thrombus formation. J.Biol.Chem. 2007 PMID: 17785464
• Szczepankiewicz Aminopyridine-based c-Jun N-terminal kinase inhibitors with cellular activity and minimal cross-kinase activity. J.Med.Chem. 2006 PMID: 16759099

Product Documents for TCS JNK 6o