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TH 1020

Catalog #: 6191 Datasheet / COA / SDS

Discontinued Product

6191 has been discontinued.
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TH 1020 | CAS No. 1841460-82-9 | Toll-like Receptor Inhibitors
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Description: Toll-like receptor (TLR) 5/Flagellin complex antagonist

Chemical Name: 4-[[4-(Phenylmethyl)-5-(4-pyridinyl)-4H-1,2,4-triazol-3-yl]thio]-pyrido[3',2':4,5]thieno[3,2-d]pyrimidine

Purity: ≥98%

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Biological Activity

TH 1020 is a toll-like receptor (TLR) 5/Flagellin complex antagonist (IC50 = 0.85 μM). Competes with flagellin for TLR5 binding to inhibit the TLR5:flagellin interaction and subsequent downstream TNF-α secretion.

Technical Data

M.Wt:
453.54
Formula:
C23H15N7S2
Solubility:
Soluble to 5 mM in DMSO with gentle warming
Purity:
≥98%
Storage:
Store at +4°C
CAS No:
1841460-82-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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