UK 5099
Chemical Name: 2-Cyano-3-(1-phenyl-1H-indol-3-yl)-2-propenoic acid
Purity: ≥98%
Biological Activity
UK 5099 is an inhibitor of plasma membrane monocarboxylate transporters (MCTs) and the mitochondrial pyruvate carrier (MPC).Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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The inhibition of pyruvate transport across the plasma membrane of the bloodstream form of Trypanosoma brucei and its metabolic implications.
Wiemer et al.
Biochem.J., 1995;312:479 -
Identification of the mitochondrial pyruvate carrier in Saccharomyces cerevisiae.
Hildyard et al.
Biochem.J., 2003;374:607 -
A molecular mechanism of pyruvate protection against cytotoxicity of reactive oxygen species in osteoblasts.
Hinoi et al.
Mol.Pharmacol., 2006;70:925
Product Datasheets
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Citations for UK 5099
The citations listed below are publications that use Tocris products. Selected citations for UK 5099 include:
7 Citations: Showing 1 - 7
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A non-canonical tricarboxylic acid cycle underlies cellular identity.
Authors: Oliver J Et al.
Nature 2022;603:477-481
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The mitochondrial carrier SFXN1 is critical for complex III integrity and cellular metabolism.
Authors: Santosh Et al.
Cell Rep 2021;34:108869
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A glycolytic shift in Schwann cells supports injured axons.
Authors: Keit Men Et al.
Nat Neurosci 2020;23:1215-1228
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Disrupting Mitochondrial Pyruvate Uptake Directs Glutamine into the TCA Cycle away from Glutathione Synthesis and Impairs Hepatocellular Tumorigenesis.
Authors: Tompkins Et al.
Cell Rep 2019;28:2608
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Metabolic Control of Astrocyte Pathogenic Activity via cPLA2-MAVS.
Authors: Lei Et al.
Cell 2019;179:1483-1498.e22
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The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity.
Authors: Rauckhorst Et al.
Mol Metab 2017;6:1468
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SCFA transport in rat duodenum.
Authors: Kaji Et al.
Nat Chem Biol 2015;308:G188
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