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Upadacitinib

Catalog #: 7783 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7783/50
Upadacitinib | CAS No. 1310726-60-3 | Jak1
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Description: JAK1-selective inhibitor

Chemical Name: (3S,4R)-3-Ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)-1-pyrrolidinecarboxamide

Purity: ≥98%

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Biological Activity

Upadacitinib is a potent and selective JAK1 inhibitor (IC50 = 47 nM). In a cellular assay, Upadacitinib shows selectivity for JAK1 over JAK2, JAK3 and TYK2 (IC50 values are 0.014 μM, 0.593 μM, 1860 μM and 2715 μM). In vivo, Upadacitinib suppresses paw swelling and bone destruction in a rat model of arthritis.

Technical Data

M.Wt:
380.37
Formula:
C17H19F3N6O
Solubility:
Soluble to 100 mM in DMSO and to 50 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
1310726-60-3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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