VH 032 amide-PEG1-acid

Tocris Bioscience | Catalog # 7104

VHL ligand with PEG linker and terminal acid for onward chemistry
Tocris Bioscience

Key Product Details

Description

VHL ligand with PEG linker and terminal acid for onward chemistry

Alternative Names

(S,R,S)-AHPC-PEG1-COOH
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Product Description

VH 032 amide-PEG1-acid is a functionalized von-Hippel-Lindau (VHL) protein ligand for PROTAC® research and development; incorporates an E3 ligase ligand plus a PEG1 linker with terminal carboxylic acid ready for conjugation to a target protein ligand. Part of a range of functionalized tool molecules for PROTAC R&D.

Please contact us for SD files of our available Degrader Building Blocks.

PROTAC® is a registered trademark of Arvinas Operations, Inc., and is used under license.

Usage Guidelines

This product is provided for use in onward chemistry. Suitable solvents can be used.

Product Specifications for VH 032 amide-PEG1-acid

Molecular Weight

574.69

Formula

C28H38N4O7S

Storage

Store at -20°C

Purity

≥95% (HPLC)

Chemical Name

3-(3-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)-3-oxopropoxy)propanoic acid

CAS Number

2172820-07-2

PubChem ID

134184040

InChI Key

HVPZHRHEHKZOOJ-TYBLODHISA-N

SMILES

CC1=C(C2=CC=C(C=C2)CNC([C@@H]3C[C@H](CN3C([C@H](C(C)(C)C)NC(CCOCCC(O)=O)=O)=O)O)=O)SC=N1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

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Background References

References are publications that support the biological activity of the product.

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Product Documents for VH 032 amide-PEG1-acid

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot or batch number in the search box below.

Product Specific Notices for VH 032 amide-PEG1-acid

For research use only

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