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Vismodegib

Catalog #: 7710 Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
7710/50
7710/10
Vismodegib | CAS No. 879085-55-9 | Hedgehog Signaling Inhibitors
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Description: Potent hedgehog pathway inhibitor

Chemical Name: 2-Chloro-N-[4-chloro-3-(2-pyridinyl)phenyl]-4-(methylsulfonyl)benzamide

Purity: ≥98%

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Biological Activity

Vismodegib is a potent hedgehog pathway inhibitor (IC50 = 3 nM). It causes tumor regressions in allograft medulloblastoma mice model and tumor growth inhibition in a xenograft mouse models of colorectal cancer. Vismodegib is orally bioavailable.

Technical Data

M.Wt:
421.3
Formula:
C19H14Cl2N2O3S
Solubility:
Soluble to 100 mM in DMSO
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
879085-55-9

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

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