VU 6001966
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Description: Potent and selective negative allosteric modulator of mGlu2 receptors
Purity: ≥98%
Biological Activity
VU 6001966 is a potent and selective mGlu2 negative allosteric modulator (IC50 = 78 nM). Exhibits > 350-fold selectivity for mGlu2 over mGlu3. Also exhibits selectivity over other mGluRs and a panel of GPCRs, ion channels and transporters. VU 6001966 induces antidepression like effects in mouse models of chronic stress. CNS penetrant.Technical Data
M.Wt:
326.33
Formula:
C17H15FN4O2
Solubility:
Soluble to 100 mM in DMSO and to 5 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
2009052-76-8
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Licensing Caveats:
Sold under license from Vanderbilt University
Background References
-
Design and synthesis of mGlu2 NAMs with improved potency and CNS penetration based on a truncated picolinamide core.
Bollinger et al.
ACS Med.Chem.Lett., 2017;8:919
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