Home / Estrogen and Related Receptor Inverse Agonists / XCT 790

XCT 790

Catalog #: 3928
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
3928/10
3928/50
XCT 790 | CAS No. 725247-18-7 | Estrogen and Related Receptor Inverse Agonists
1 Image
Description: Selective ERRα inverse agonist

Chemical Name: 3-[4-(2,4-Bis-trifluoromethylbenzyloxy)-3-methoxyphenyl]-2-cyano-N-(5-trifluoromethyl-1,3,4-thiadiazol-2-yl)acrylamide

Purity: ≥99%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

XCT 790 is a selective ERRα inverse agonist (IC50 = ~400 nM). Displays no antagonist activity at ERRγ or ERα at concentrations below 10 μM. Interferes with PPARγ coactivator-1α (PGC-1α)/ERRα-dependent signaling: inhibits PGC-1α induction of ERRα and MAO-B gene expression and downregulates the constitutive transcriptional activity of ERRα in numerous cell lines.

Technical Data

M.Wt:
596.42
Formula:
C23H13F9N4O3S
Solubility:
Soluble to 10 mM in DMSO with gentle warming
Purity:
≥99%
Storage:
Store at +4°C
CAS No:
725247-18-7

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERR?
    S Bae, MJ Lee, SH Mun, EG Giannopoul, V Yong-Gonza, JR Cross, K Murata, V Giguère, M van der Me, KH Park-Min
    J. Clin. Invest., 2017;0(0):.
  2. Potentiation of ICI182,780 (Fulvestrant)-induced estrogen receptor-alpha degradation by the estrogen receptor-related receptor-α inverse agonist XCT790.
    Lanvin et al.
    J.Biol.Chem., 2007;282:28328
  3. Peroxisome proliferator-activated receptor γ coactivator-1α enhances antiproliferative activity of 5'-deoxy-5-fluorouridine in cancer cells through induction of uridine phosphorylase.
    Kong et al.
    Mol.Pharmacol., 2009;76:854
  4. Regulation of PPARγ coactivator 1α (PGC-1α) signaling by an estrogen-related receptor alpha (ERRα) ligand.
    Willy et al.
    Proc.Natl.Acad.Sci.USA, 2004;101:8912
  5. Network-based screen in iPSC-derived cells reveals therapeutic candidate for heart valve disease.
    Theodoris et al.
    Science., 2021;371

Product Datasheets

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Reconstitution Calculator

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Citations for XCT 790

The citations listed below are publications that use Tocris products. Selected citations for XCT 790 include:

4 Citations: Showing 1 - 4

  1. The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation.
    Authors: Núria Et al.
    Cell Metab  2021;33:379-394.e8
  2. Estrogen related receptor α (ERRα) a promising target for the therapy of adrenocortical carcinoma (ACC).
    Authors: Michael P Et al.
    Oncotarget  2015;6:25135-48
  3. Development of a stable cell line with an intact PGC-1α/ERRα axis for screening environmental chemicals.
    Authors: Teng Et al.
    Mol Cancer  2014;444:177
  4. Estrogen-related receptor α is required for efficient human cytomegalovirus replication.
    Authors: Hwang Et al.
    Proc Natl Acad Sci U S A  2014;111:E5706

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