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Zebularine

Catalog #: 2293
4 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
2293/10
Zebularine | CAS No. 3690-10-6 | Methyltransferase Inhibitors
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Description: DNA methyltransferase and cytidine deaminase inhibitor
Alternative Names: NSC 309132

Chemical Name: 1-β-D-Ribofuranosyl-2(1H)-pyrimidinone

Purity: ≥99%

Product Details
Citations (4)
Reviews
Biological Activity Technical Data Background Product Datasheets Calculators

Biological Activity

Zebularine is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Inhibits cytidine deaminase (Ki ~ 2 μM); induces differentiation of mesenchymal stem cells into cardiomyocytes.

Technical Data

M.Wt:
228.2
Formula:
C9H12N2O5
Solubility:
Soluble to 100 mM in water and to 100 mM in DMSO
Purity:
≥99%
Storage:
Desiccate at RT
CAS No:
3690-10-6

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Background References

  1. Potent inhibitors for the deamination of cytosine arabinoside and 5-aza-2'-deoxycytidine by human cytidine deaminase.
    Laliberte et al.
    Cancer Chemother.Pharmacol., 1992;30:7
  2. Metabolic activation of zebularine, a novel DNA methylation inhibitor, in human bladder carcinoma cells.
    Ben-Kasus et al.
    Biochem.Pharmacol., 2005;70:121
  3. DNA methylation inhibitors, 5-azacytidine and zebularine potentiate the trans-differentiation of rat bone marrow mesenchymal stem cells into cardiomyocytes.
    Naeem et al.
    Cardiovasc.Ther. [Epub ahead of print], 2012;

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Citations for Zebularine

The citations listed below are publications that use Tocris products. Selected citations for Zebularine include:

4 Citations: Showing 1 - 4

  1. The DNA Methylation Inhibitor Zebularine Controls CD4+ T Cell Mediated Intraocular Inflammation.
    Authors: Zou Et al.
    Front Immunol  2019;10:1950
  2. Activation of ERK1/2 by store-operated calcium entry in rat parotid acinar cells.
    Authors: Soltoff and Lannon
    PLoS One  2013;8:e72881
  3. DNA methylation mediates the discriminatory power of associative long-term memory in honeybees.
    Authors: Biergans Et al.
    PLoS One  2012;7:e39349
  4. Haploinsufficiency of Dnmt1 impairs leukemia stem cell function through derepression of bivalent chromatin domains.
    Authors: Trowbridge Et al.
    Gastroenterology  2012;26:344

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