Zotepine
Chemical Name: 2-[(8-Chlorodibenzo(Z)[b,f]thiepin-10-yl)oxy]-N,N-dimethylethanamine
Purity: ≥99%
Biological Activity
5-HT2A receptor and dopamine D2 receptor antagonist (Ki values are 0.69 and 2.3 nM respectively). Also a potent histamine H1 receptor antagonist (IC50 = 8.0 nM). Atypical antipsychotic; exhibits antidepressive and anxiolytic effects in vivo.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Inverse agonist activity of atypical antipsychotic drugs at human 5-hydroxytryptamine2C receptors.
Herrick-Davis et al.
J.Pharmacol.Exp.Ther., 2000;295:226 -
Effects of zotepine on extracellular levels of monamine, GABA and glutamate in rat prefrontal cortex.
Yamamura et al.
Br.J.Pharmacol., 2009;157:656 -
Norzotepine, a major metabolite of zotepine, exerts atypical antipsychotic-like and antidepressant-like actions through its potent inhibition of NE reuptake.
Shobo et al.
J.Pharmacol.Exp.Ther., 2010;333:772
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