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Podocyte Markers

Clicking on a molecule name will take you to our selection of antibodies, proteins, small molecules, immunoassays, and enzymatic assays for that molecule.

Kidney Cells Podocytes Glomerular Basement Membrane Parietal Epithelium Mesangial Cells Glomerular Endothelium Macula Densa Tubule Epithelium

Osteopontin/OPN

Secreted Factors

Agrin

Angiopoietin-like Proteins

Angiopoietins

Apolipoprotein L1

BMP-7

Chemokines

Collagen IV alpha 1

Endorepellin/Perlecan

Endothelin-1

HB-EGF

Heparanase/HPSE

IGFBP-rp1/IGFBP-7

IL-6

MIF

MMPs

Nesfatin-1/
Nucleobindin 2

Serpin E1/PAI-1

sFRP1

TGF-beta 1

VEGFs

Cell Surface Markers

5-HT Receptors

Adenosine Receptors

Adrenergic Receptors

Angiotensin Receptors

Cadherin-13

CD151

Claudin-1

CLIC5

Connexin 43/GJA1

CRB3/Crumbs

CXADR/CAR

CXCR4

DDR1

Dopamine Receptors

Dystroglycan

E-Cadherin

EGFR

Endothelin Receptors

Ephrin-B2

FAT1

FCRN

Glut Transporters

gp130

HGFR/c-MET

ICAM-1/CD54

IL-17 RA/IL-17 R

IL-6 R

ILDR1

ILDR2

Insulin R/CD220

Integrins

JAM-A

Kirrels

Lipolysis Stimulated
Receptor

LRP-6

Megalin/LRP2

Muscarinic ACh
Receptor M5

MyD88

Nephrin

Neprilysin/CD10

Neuropilins

Notch

Occludin

Opioid Receptors

PAFR

PAR2

P-Cadherin

Plexins

Podocalyxin

Podocan

Podoplanin

Prostanoid Receptors

PTH1R/PTHR1

PTP Isoforms

Purinergic Receptors

RAGE

Renin R

ROBO2

Semaphorins

SIRP alpha/CD172a

SLC7A6/LAT3

Syndecans

THSD7A

TLRs

TMEM47

TNF RI/TNFRSF1A

TRPC6

Vang-like Protein 2/
VANGL2

VCAM-1/CD106

VEGF Receptors

Intracellular Markers

Actin Isoforms

Actin-related Proteins

AKAP12

Akt Isoforms

alpha-Actinin 4

AMPK

AP-2

ASXL1

ATF3

ATG Isoforms

Bad

Bax

beta-Arrestin

Calcineurin

CaMKII

CASK

Caspase-3

Catenins

Cathepsin L

CD2AP

CDC42

cGK1/PRKG1

CIN85/RukL

Cingulin

Clathrin

Cofilin 1

Cortactin

COX-2

CREB

Crk

CSE

Desmin

Dynamin

Endophilin

Exostosin 1

Ezrin

FAK

Filamin B

FMN2

Fox Transcription
Factors

Fyn

GGA2

Grb2

GSK-3

Hey1

HSP27

ILK
(integrin-
linked kinase)

IQGAP1

IRS Proteins

ZEB2

LMX1b

MAD2L2

MAFb

MAGI Proteins

MAPK

MICAL-1

MIG2/Kindlin-2

Myosin Isoforms

NCK Proteins

Nestin

NFAT

NKkB p65

NLRP3

NMIIA
(non-muscle myosin)

NOX4

N-WASP

OSR1

p130Cas

p21/CIP1/CDKN1A

p27/Kip1

p53

Palladin

Par3

PARD6A

Parvins

Pax Transcription
Factors

Paxillin

PGC1-alpha

PI 3-Kinase
Isoforms

PINCH-1

PKC

PLCL3

Podicin

Polycystin-1/PKD1

PP1

PP2A

PPAR Transcription
Factors

PTEN

PTP1B

Rab Proteins

Rac

RhoA

S100A4

Scribble

Septins

SHIP2

SHP

SIRT1

Smad3

Snail1

SNAP23

Sortilin

Src

Synaptojanin-1

Synaptopodin

Syntaxin-4

Syntrophin

TAK1

Talin1

TCF21

TEF1/TCF13

TENC1

Tight Junction
Proteins

TLRs

TOR

TORC1

TSC Proteins

TXNIP

VAMP-2

Vimentin

Vinculin

WT1

Zyxin

Podicin

Overview

Podocytes Cell Overview

Podocytes are specialized epithelial cells that cover the abluminal surfaces of glomerular capillaries. They extend branching and interdigitating foot processes connected by slit diaphragms rich in Nephrin, Kirrel/NEPH, and Podocin. Slit diaphragms contribute to the selectivity of the filtration barrier, allowing free filtration of water and small solutes but not macromolecules. Podocytes attach to the glomerular basement membrane (GBM) through Syndecan, Dystroglycan, and Integrin a3b1 adhesion which transduce signals to regulate filtration. Barrier dysfunction results from podocyte detachment, genetic mutation of adhesion proteins, inflammation, metabolic disorders, and diabetes. Podocyte injury leads to Albumin loss through the filtration barrier (proteinuria), an early indicator of kidney damage. Progression of the damage leads to nephrotic syndrome, chronic kidney disease (CKD), and end stage renal disease (ESRD), conditions which require kidney dialysis or transplantation.

Related Information

Interactive Pathway: Renin - Angiotensin Pathways