Human IFN-gamma High Sensitivity Magnetic Luminex® Performance Assay

Name: Human IFN-gamma High Sensitivity Magnetic Luminex® Performance Assay
Brand: R&D Systems
SKU: LHSCM285

Catalog #: LHSCM285 Datasheet / COA / SDS

Discontinued Product

LHSCM285 has been discontinued and is replaced by LHSCM285B.

R&D Systems Luminex High Performance Panel - Magnetic

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Citations (5)

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Human IFN-gamma High Sensitivity Magnetic Luminex® Performance Assay Summary

Assay Type	bead-based multiplex assay for the Luminex^® platform
Format	1 x 96-well microplate and antibody-coated beads
Analytes Detected	Please see analyte list in assay customization tool below.
Performance Validation	Luminex Assays are validated for use with cell culture supernatants, plasma and serum. All Luminex assays are tested for sensitivity, intra-assay precision, inter-assay precision and to ensure assay linearity for validated sample types. Antibody pairs are selected and tested to confirm the parallel detection of natural and recombinant standard protein and to ensure the accurate determination of target analytes within biological samples. Assays for each target analyte are screened against all target analytes to confirm low antibody cross-reactivity. For standard curves, intra-assay and inter-assay precision, recovery, and linearity data for the different analyte-specific beads, please see product datasheets for corresponding individual Bead Sets (below).

Not finding your analyte of interest? View our complete Luminex offering in the full version of our Luminex Assay Customization Tool. We also offer Custom Luminex Services.

Which Luminex Assay is right for me?

Assays for the Luminex platform are offered as High Performance Assays or Assays. The Luminex High Performance Assays are fully validated panels with a focused selection of analytes. They are available in We Mix, You Mix, and Predetermined formats. The Luminex Assays allows for the maximum number of analytes in a multiplex and is supplied as a premixed kit. View a table comparing the features and benefits of these bead-based multiplex assays.

Background: IFN-gamma

IFN-gamma (Interferon-gamma) is the prototype proinflammatory cytokine and is produced by a variety of immune cells under inflammatory conditions, notably by T cells and NK cells. It plays a key role in host defense by promoting the development and activation of Th1 cells, chemoattraction and activation of monocytes and macrophages, upregulation of antigen presentation molecules, and immunoglobulin class switching in B cells. It also exhibits antiviral, antiproliferative, and apoptotic effects. In addition, IFN-gamma functions as an anti-inflammatory mediator by promoting the development of regulatory T cells and inhibiting Th17 cell differentiation. IFN-gamma dimers signal through a receptor complex of two IFN-gamma R1 and two IFN-gamma R2 subunits.

Long Name

Interferon gamma

Entrez Gene IDs

3458 (Human); 15978 (Mouse); 25712 (Rat); 396991 (Porcine); 281237 (Bovine); 403801 (Canine); 493965 (Feline)

Alternate Names

IFG; IFI; IFNG; IFNgamma; IFN-gamma; Immune interferon; interferon gamma; interferon, gamma

Product Datasheets

COA

SDS

Product Specific Notices

Luminex® is a registered trademark of Luminex Corporation.

Citations for Human IFN-gamma High Sensitivity Magnetic Luminex® Performance Assay

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

5 Citations: Showing 1 - 5
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Transforming growth factor-beta profiles correlate with clinical symptoms and parameters of haemostasis and inflammation in a controlled human malaria infection
Authors: GM de Jong, MBB McCall, WA Dik, RT Urbanus, LJ Wammes, R Koelewijn, RW Sauerwein, A Verbon, JJ van Hellem, PJJ van Gender
Cytokine, 2019-09-13;125(0):154838.
Species: Human
Sample Types: Serum
Patients with idiopathic recurrent miscarriage have abnormally high TGFï¿½+ blood NK, NKT and T cells in the presence of abnormally low TGFï¿½ plasma levels
Authors: L Zhu, M Aly, RJ Kuon, B Toth, H Wang, H Karakizlis, R Weimer, C Morath, E Ibrahim, N Ekpoom, G Opelz, V Daniel
BMC Immunol., 2019-03-04;20(1):10.
Species: Human
Sample Types: Plasma
?-3 fatty acids-supplementary in gestation alleviates neuroinflammation and modulates neurochemistry in rats
Authors: M Tang, R Dang, S Liu, M Zhang, Y Zheng, R Yang, T Yin
Lipids Health Dis, 2018-11-03;17(1):247.
Species: Rat
Sample Types: Serum
Cytokines and Postoperative Delirium in Older Patients Undergoing Major Elective Surgery.
Authors: Vasunilashorn S, Ngo L, Inouye S, Libermann T, Jones R, Alsop D, Guess J, Jastrzebski S, McElhaney J, Kuchel G, Marcantonio E
J Gerontol A Biol Sci Med Sci, 2015-07-27;0(0):.
Species: Human
Sample Types: Plasma
Clinical Scale Zinc Finger Nuclease-mediated Gene Editing of PD-1 in Tumor Infiltrating Lymphocytes for the Treatment of Metastatic Melanoma.
Authors: Beane J, Lee G, Zheng Z, Mendel M, Abate-Daga D, Bharathan M, Black M, Gandhi N, Yu Z, Chandran S, Giedlin M, Ando D, Miller J, Paschon D, Guschin D, Rebar E, Reik A, Holmes M, Gregory P, Restifo N, Rosenberg S, Morgan R, Feldman S
Mol Ther, 2015-05-05;23(8):1380-90.
Species: Human
Sample Types: Cell Culture Supernates