R&D Systems Range of Antibodies for G Protein-Coupled Receptors
G protein-coupled receptors (GPCRs) are the largest family of membrane receptors. As such, drug discovery has focused on this receptor family. Approximately 35% of all FDA-approved drugs target GPCRs. However, this represents only a small proportion of the 800 human GPCRs. This is due, in part, to orphan GPCRs still being understudied, as well as the heterogeneous nature of GPCRs, their endogenous ligands, and their binding sites. Efforts to elucidate the structure, biology, and therapeutic potential of non-targeted GPCRs is ongoing and continues to drive the development of GPCR-based therapeutics. R&D Systems offers a large selection of highly validated GPCR antibodies for supporting basic research and drug development.
The graphic below illustrates the number of antibodies we offer for different GPCR subfamilies. Click on the family names to explore the antibodies and other research tools available for the GPCRs in that family. To explore an expanded selection of antibodies for analyzing GPCRs and GPCR signaling, visit the GPCR page on the Novus Biologicals website.
Additionally, visit our Antibodies for G Protein-Coupled Receptors (GPCRs) page to learn about the challenges in GPCR antibody production and how R&D Systems overcomes these challenges to produce the highest performing GPCR antibodies in the industry.
Sensory
Sensory
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Class B2 (Adhesion)
Class B2 (Adhesion)
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Adhesion
Adhesion
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Adhesion
class
GPCRs
class
GPCRs
Adhesion
class
GPCRs
class
GPCRs
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Class C (Glutamate)
Class C (Glutamate)
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Ion
Ion
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Calcium-
sensing
receptor
sensing
receptor
Calcium-
sensing
receptor
sensing
receptor
Amino Acid
Amino Acid
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GABA B
receptors
receptors
GABA B
receptors
receptors
Metabotropic
glutamate
receptors
glutamate
receptors
Metabotropic
glutamate
receptors
glutamate
receptors
Orphan
Orphan
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Sensory
Sensory
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Class C
orphans
orphans
Class C
orphans
orphans
Taste 1
receptors
receptors
Taste 1
receptors
receptors
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Class F (Frizzled)
Class F (Frizzled)
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Protein
Protein
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Class
frizzled
GPCRs
frizzled
GPCRs
Class
frizzled
GPCRs
frizzled
GPCRs
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Class T (Taste 2)
Class T (Taste 2)
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Sensory
Sensory
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Taste 2
receptors
receptors
Taste 2
receptors
receptors
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Class A (Rhodopsin)
Class A (Rhodopsin)
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Protein
Protein
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Chemerin
receptors
receptors
Chemerin
receptors
receptors
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Chemokine
receptors
receptors
Chemokine
receptors
receptors
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Glycoprotein
hormone
receptors
hormone
receptors
Glycoprotein
hormone
receptors
hormone
receptors
Prokineticin
receptors
receptors
Prokineticin
receptors
receptors
Sensory
Sensory
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Opsin receptors
Opsin receptors
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Steroid
Steroid
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Bile acid receptor
Bile acid receptor
G protein-coupled
estrogen receptor
estrogen receptor
G protein-coupled
estrogen receptor
estrogen receptor
Aminergic
Aminergic
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Adrenoceptors
Adrenoceptors
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5-Hydroxytryptamine
receptors
receptors
5-Hydroxytryptamine
receptors
receptors
Dopamine
receptors
receptors
Dopamine
receptors
receptors
Acetylcholine
receptors
(muscarinic)
receptors
(muscarinic)
Acetylcholine
receptors
(muscarinic)
receptors
(muscarinic)
Histamine
receptors
receptors
Histamine
receptors
receptors
Trace
amine
receptor
amine
receptor
Trace
amine
receptor
amine
receptor
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Peptide
Peptide
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Angiotensin
receptors
receptors
Angiotensin
receptors
receptors
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Apelin
receptor
receptor
Apelin
receptor
receptor
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Bombesin
receptors
receptors
Bombesin
receptors
receptors
Bradykinin
receptors
receptors
Bradykinin
receptors
receptors
Cholecystokinin
receptors
receptors
Cholecystokinin
receptors
receptors
Endothelin
receptors
receptors
Endothelin
receptors
receptors
Formylpeptide
receptors
receptors
Formylpeptide
receptors
receptors
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Complement
peptide
receptors
peptide
receptors
Complement
peptide
receptors
peptide
receptors
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Galanin
receptors
receptors
Galanin
receptors
receptors
Gonadotrophin-
releasing
hormone
receptors
releasing
hormone
receptors
Gonadotrophin-
releasing
hormone
receptors
releasing
hormone
receptors
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Ghrelin
receptor
receptor
Ghrelin
receptor
receptor
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Kisspeptin
receptor
receptor
Kisspeptin
receptor
receptor
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Melanocortin
receptors
receptors
Melanocortin
receptors
receptors
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Melanin-
concentrating
hormone
receptors
concentrating
hormone
receptors
Melanin-
concentrating
hormone
receptors
concentrating
hormone
receptors
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Neuropeptide
Y receptors
Y receptors
Neuropeptide
Y receptors
Y receptors
Motilin
receptor
receptor
Motilin
receptor
receptor
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Neuropeptide
U receptors
U receptors
Neuropeptide
U receptors
U receptors
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Neuropeptide W/
Neuropeptide B
receptors
Neuropeptide B
receptors
Neuropeptide W/
Neuropeptide B
receptors
Neuropeptide B
receptors
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Neuropeptide
S receptor
S receptor
Neuropeptide
S receptor
S receptor
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Neuropeptide FF/
Neuropeptide
AF receptors
Neuropeptide
AF receptors
Neuropeptide FF/
Neuropeptide
AF receptors
Neuropeptide
AF receptors
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Prolactin-
releasing
peptide
receptor
releasing
peptide
receptor
Prolactin-
releasing
peptide
receptor
releasing
peptide
receptor
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Neurotensin
receptors
receptors
Neurotensin
receptors
receptors
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Orexin
receptors
receptors
Orexin
receptors
receptors
Opioid
receptors
receptors
Opioid
receptors
receptors
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Proteinase-
activated receptors
activated receptors
Proteinase-
activated receptors
activated receptors
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QRFP receptor
QRFP receptor
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Relaxin family
peptide receptors
peptide receptors
Relaxin family
peptide receptors
peptide receptors
Somatostatin
receptors
receptors
Somatostatin
receptors
receptors
Urotensin
receptor
receptor
Urotensin
receptor
receptor
Tachykinin
receptors
receptors
Tachykinin
receptors
receptors
Thyrotropin-
releasing hormone
receptors
releasing hormone
receptors
Thyrotropin-
releasing hormone
receptors
releasing hormone
receptors
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Vasopressin
and oxytocin
receptors
and oxytocin
receptors
Vasopressin
and oxytocin
receptors
and oxytocin
receptors
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Lipid
Lipid
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Free
fatty acid
receptors
fatty acid
receptors
Free
fatty acid
receptors
fatty acid
receptors
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Lysophospholipid
(LPA) receptors
(LPA) receptors
Lysophospholipid
(LPA) receptors
(LPA) receptors
Cannabinoid
receptors
receptors
Cannabinoid
receptors
receptors
Lysophospholipid
(S1P) receptors
(S1P) receptors
Lysophospholipid
(S1P) receptors
(S1P) receptors
Platelet-activating
factor receptor
factor receptor
Platelet-activating
factor receptor
factor receptor
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GPR18, GPR55,
GPR119
GPR119
GPR18, GPR55,
GPR119
GPR119
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Prostanoid
receptors
receptors
Prostanoid
receptors
receptors
Leukotriene
receptors
receptors
Leukotriene
receptors
receptors
Melatonin
Melatonin
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Melatonin
receptors
receptors
Melatonin
receptors
receptors
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Orphan
Orphan
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Class A
orphans
orphans
Class A
orphans
orphans
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Nucleotide
Nucleotide
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P2Y
receptors
receptors
P2Y
receptors
receptors
Adenosine
receptors
receptors
Adenosine
receptors
receptors
Alicarboxylic Acid
Alicarboxylic Acid
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Hydroxycarboxylic
acid receptors
acid receptors
Hydroxycarboxylic
acid receptors
acid receptors
Succinate receptor
Succinate receptor
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Oxoglutarate receptor
Oxoglutarate receptor
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Class B1 (Secretin)
Class B1 (Secretin)
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Peptide
Peptide
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VIP and PACAP
receptors
receptors
VIP and PACAP
receptors
receptors
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Parathyroid
hormone
receptors
hormone
receptors
Parathyroid
hormone
receptors
hormone
receptors
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Glucagon
receptor
family
receptor
family
Glucagon
receptor
family
receptor
family
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Corticotropin-
releasing factor
receptors
releasing factor
receptors
Corticotropin-
releasing factor
receptors
releasing factor
receptors
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Calcitonin
receptors
receptors
Calcitonin
receptors
receptors
