(1S,3R)-ACPD
Chemical Name: (1S,3R)-1-Aminocyclopentane-1,3-dicarboxylic acid
Purity: ≥98%
Biological Activity
(1S,3R)-ACPD is an active isomer of (±)-trans-ACPD. Agonist at both group I and II mGlu receptors (EC50 values are 5, 15, 42 and 60 μM at mGluR2, mGluR5, mGluR1 and mGluR6 respectively).NPEC-caged-(1S,3R)-ACPD, (±)-trans-ACPD and cis-ACPD also available.
Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Background References
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Astrocyte inositol triphosphate receptor type 2 and cytosolic phospholipase A2 alpha regulate arteriole responses in mouse neocortical brain slices.
He L, Linden D, Sapirstein A
PLoS ONE, 2102;7(8):e42194. -
N-type voltage gated calcium channels mediate excitatory synaptic transmission in the anterior cingulate cortex of adult mice.
Kang S, Liu M, Shi T, Zhao M, Kaang B, Zhuo M
Mol Pain, 2013;9(0):58. -
Synthesis and pharmacology of 3-hydroxy-Δ2-isoxazoline-cyclopentance analogues of glutamic acid.
Conti et al.
Farmaco, 2002;57:889 -
Metabotropic glutamate receptors: novel targets for drug development.
Knopfel et al.
J.Med.Chem., 1995;38:1417 -
Differences in agonist and antagonist activities for two indicies of metabotropic glutamate receptor-stimulated phosphoinositide turnover.
Mistry and Challis
Br.J.Pharmacol., 1996;117:1735
Product Datasheets
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Citations for (1S,3R)-ACPD
The citations listed below are publications that use Tocris products. Selected citations for (1S,3R)-ACPD include:
6 Citations: Showing 1 - 6
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HTS-compatible FRET-based conformational sensors clarify membrane receptor activation.
Authors: Scholler
Nat Chem Biol 2017;13(4):372
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Stimulation-evoked Ca2+ signals in astrocytic processes at hippocampal CA3-CA1 synapses of adult mice are modulated by glutamate and ATP.
Authors: Tang Et al.
J Neurosci 2015;35:3016
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Drep-2 is a novel synaptic protein important for learning and memory.
Authors: Andlauer Et al.
J Neurosci 2014;3
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A modulatory effect of the feedback from higher visual areas to V1 in the mouse.
Authors: Pasquale and Sherman
J Neurophysiol 2013;109:2618
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Tone-dependent vascular responses to astrocyte-derived signals.
Authors: Blanco Et al.
Am J Physiol Heart Circ Physiol 2008;294:H2855
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Long-range axonal calcium sweep induces axon retraction.
Authors: Yamada Et al.
Sci Adv 2008;28:4613
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