Home / Group I mGluR Agonists / (±)-trans-ACPD

(±)-trans-ACPD

Catalog #: 0187
7 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
0187/10
0187/50
(±)-trans-ACPD | CAS No. 67684-64-4 | Group I mGluR Agonists
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Description: Group I and II mGlu agonist

Chemical Name: (±)-1-Aminocyclopentane-trans-1,3-dicarboxylic acid

Purity: ≥99%

Product Details
Citations (7)
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Biological Activity

(±)-trans-ACPD is an equimolecular mixture of (1S,3R)- and (1R,3S)-ACPD. Selective agonist for metabotropic glutamate receptors; active at both group I and group II mGlu receptors (EC50 values are 2, 15, 23 and ~800 μM at mGluR2, mGluR1, mGluR5 and mGluR4 respectively).

(1S,3R)-ACPD and cis-ACPD also available.

Technical Data

M.Wt:
173.17
Formula:
C7H11NO4
Solubility:
Soluble to 5 mM in water with gentle warming and to 50 mM in 1eq. NaOH
Purity:
≥99%
Storage:
Store at RT
CAS No:
67684-64-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

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Citations for (±)-trans-ACPD

The citations listed below are publications that use Tocris products. Selected citations for (±)-trans-ACPD include:

7 Citations: Showing 1 - 7

  1. Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors.
    Authors: Rojas Et al.
    Mol Pharmacol  2013;83:106
  2. Activity Modes in Thalamocortical Relay Neurons are Modulated by G(q)/G(11) Family G-proteins - Serotonergic and Glutamatergic Signaling.
    Authors: Coulon Et al.
    Front Cell Neurosci  2011;4:132
  3. Long-term modifications in the strength of excitatory associative inputs in the piriform cortex.
    Authors: Young and Sun
    Chem Senses  2007;32:783
  4. Calcium increases in retinal glial cells evoked by light-induced neuronal activity.
    Authors: Newman
    J Neurosci  2005;25:5502
  5. PropF. suppresses synaptic responsiveness of somatosensory relay neurons to excitatory input by potentiating GABA(A) receptor chloride channels.
    Authors: Ying and Goldstein
    Mol Pain  2005;1:2
  6. Bidirectional synaptic plasticity in the cerebellum-like mammalian dorsal cochlear nucleus.
    Authors: Fujino and Oertel
    Proc Natl Acad Sci U S A  2003;100:265
  7. Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling.
    Authors: Nishi Et al.
    Proc Natl Acad Sci U S A  2003;100:1322

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