A66
Chemical Name: (2S)-N1-[2-(1,1-Dimethylethyl)-4'-methyl[4,5'-bithiazol]-2'-yl]-1,2-pyrrolidinedicarboxamide
Purity: ≥98%
Biological Activity
A66 is a potent and selective PI 3-kinase p110α inhibitor (IC50 = 32 nM). Exhibits >100-fold selectivity for p110α over other PI 3-kinase isoforms. Inhibits Akt signaling and tumor growth in SK-OV-3 xenografts in mice.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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HLA Class II-Triggered Signaling Cascades Cause Endothelial Cell Proliferation and Migration: Relevance to Antibody-Mediated Transplant Rejection
YP Jin, NM Valenzuela, X Zhang, E Rozengurt, EF Reed
J. Immunol., 2018;0(0):. -
Insulin Receptor and GPCR Crosstalk Stimulates YAP via PI3K and PKD in Pancreatic Cancer Cells
F Hao, Q Xu, Y Zhao, JV Stevens, SH Young, J Sinnett-Sm, E Rozengurt
Mol. Cancer Res., 2017;0(0):. -
A drug targeting only p110α can block phosphoinositide 3-kinase signalling and tumour growth in certain cell types.
Jamieson et al.
Biochem. J., 2011;438:53
Product Datasheets
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Citations for A66
The citations listed below are publications that use Tocris products. Selected citations for A66 include:
3 Citations: Showing 1 - 3
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Dominant Role of PI3K p110α over p110β in Insulin and β-Adrenergic Receptor Signalling.
Authors: Christos Et al.
Int J Mol Sci 2021;22
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Growth and Viability of Cutaneous Squamous Cell Carcinoma Cell Lines Display Different Sensitivities to Isoform-Specific Phosphoinositide 3-Kinase Inhibitors.
Authors: Tania Et al.
Int J Mol Sci 2021;22
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Increased mitochondrial and lipid metabolism is a conserved effect of Insulin/PI3K pathway downregulation in adipose tissue.
Authors: Eugene Et al.
Sci Rep 2020;10:3418
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