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ALX 5407 hydrochloride

Catalog #: 1757
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ALX 5407 hydrochloride | CAS No. 200006-08-2 | Glycine Transporter Inhibitors
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Description: Selective non-transportable GlyT1 inhibitor
Alternative Names: (+)-NFPS

Chemical Name: N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride

Purity: ≥98%

Product Details
Citations (1)
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Biological Activity

ALX 5407 hydrochloride is a selective non-transportable inhibitor of the glycine transporter GlyT1 (IC50 values are 3 nM and > 100 μM for human GlyT1c and GlyT2 respectively). Does not recognize other glycine sites, including the glycine site on the NMDA receptor (IC50 > 100 μM).

Racemate also available.

Technical Data

M.Wt:
429.92
Formula:
C24H24FNO3.HCl
Solubility:
Soluble to 50 mM in ethanol and to 100 mM in DMSO
Purity:
≥98%
Storage:
Desiccate at +4°C
CAS No:
200006-08-2

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Licensing Caveats:
Sold with the permission of NPS Pharmaceuticals Inc. Strictly for in vitro use only
Other Product-Specific Information:

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Citation for ALX 5407 hydrochloride

The citations listed below are publications that use Tocris products. Selected citations for ALX 5407 hydrochloride include:

1 Citation: Showing 1 - 1

  1. Inhibition of glycine transporter-1 in the dorsal vagal complex improves metabolic homeostasis in diabetes and obesity.
    Authors: Yue Et al.
    Nat.Commun.  2016;7:13501

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