Home / Glycine Transporter Inhibitors / ASP 2535

ASP 2535

Catalog #: 5308
2 Citations Datasheet / COA / SDS
Catalog # Availability Size / Price Qty
5308/10
ASP 2535 | CAS No. 374886-51-8 | Glycine Transporter Inhibitors
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Description: Potent and selective GlyT1 inhibitor

Chemical Name: 4-[3-(1-Methylethyl)-5-(6-phenyl-3-pyridinyl)-4H-1,2,4-triazol-4-yl]-2,1,3-benzoxadiazole

Purity: ≥98%

Product Details
Citations (2)
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Biological Activity

ASP 2535 is a potent and selective GlyT1 inhibitor (IC50 = 92 nM). Exhibits 50-fold selectivity over GlyT2. Attenuates MK 801-induced working memory deficits and PCP-induced visual learning deficits in mice. Orally available and brain penetrant.

Technical Data

M.Wt:
382.42
Formula:
C22H18N6O
Solubility:
Soluble to 100 mM in DMSO and to 100 mM in ethanol
Purity:
≥98%
Storage:
Store at -20°C
CAS No:
374886-51-8

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets

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Citations for ASP 2535

The citations listed below are publications that use Tocris products. Selected citations for ASP 2535 include:

2 Citations: Showing 1 - 2

  1. Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation.
    Authors: Ostrovskaya Et al.
    Oncotarget  2014;21:74
  2. Neuroprotective effect of novel cognitive enhancer noopept on AD-related cellular model involves the attenuation of apoptosis and tau hyperphosphorylation.
    Authors: Rita U Et al.
    J Biomed Sci  2014;21:74

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