Phencyclidine hydrochloride
Chemical Name: 1-(1-Phenylcyclohexyl)piperidine hydrochloride
Purity: ≥99%
Biological Activity
Phencyclidine hydrochloride is a non-competitive NMDA receptor antagonist and sigma receptor agonist. Psychostimulant; induces rotational behavior, head-weaving and cognitive dysfunction in rats.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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The involvement of σ receptors in the choice reaction performance deficits induced by phencyclidine.
Jin et al.
Eur.J.Pharmacol., 1997;319:147 -
Phencyclidine (PCP) acts at σ sites to induce c-fos gene expression.
Sharp
Brain Res., 1997;758:51 -
Synthesis and binding properties of MK-801 isothiocyanates; (+)-3-isothiocyanato-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imine hydrochloride: a new potent and selective electrophilic affinity ligand for the NMDA receptor-c
Linders et al.
J.Med.Chem., 1993;36:2499
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