ELA-14 (human)
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Description: Potent apelin agonist; bioactive fragment of ELA-32 (Cat. No. 6291)
Alternative Names: ELA (19-32) (human),ELABELA
Biological Activity
ELA-14 (human) is a potent apelin (APJ) receptor agonist (Ki = 0.93 nM). Bioactive fragment of ELA-32 (Cat. No. 6291). Activates Gαi1 pathway and β-arrestin-2 recruitment. Reduces arterial pressure in rat hearts. Active in vivo.ELA-14 negative control (Cat.No. 6294) also available.
Technical Data
M.Wt:
1707.03
Formula:
C75H119N25O17S2
Sequence:
XRRCMPLHSRVPFP
(Modifications: X = Glp)
Solubility:
Soluble to 1 mg/ml in water
Storage:
Store at -20°C
CAS No:
1886973-05-2
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Additional Information
Licensing Caveats:
Sold under agreement from the Agency for Science, Technology and Research (A*STAR), ETPL, and affiliates including the Institute of Medical Biology.
Background References
-
Discovery and structure-activity relationship of a bioactive fragment of ELABELA that modulates vascular and cardiac functions.
Murza et al.
J.Med.Chem., 2016;59:2962
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