FPL 64176
Chemical Name: 2,5-Dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylic acid methyl ester
Purity: ≥99%
Biological Activity
FPL 64176 is a potent activator of L-type Ca2+ channels (EC50 = 16 nM). 40-fold more potent than Bay K 8644 (Cat. No. 1544) as a positive inotrope in guinea pig atria.Technical Data
The technical data provided above is for guidance only.
For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Background References
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Discovery and synthesis of methyl 2,5-dimethyl-4-[2-(phenylmethyl)benzoyl]-1H-pyrrole-3-carboxylate (FPL 64176) and analogues: the first examples of a new class of calcium channel activator.
Baxter et al.
J.Med.Chem., 1993;36:2739 -
Comparison of the in vitro and in vivo cardiovascular effects of two structurally distinct Ca++ channel activators, BAY K 8644 and FPL 64176.
Rampe et al.
J.Pharmacol.Exp.Ther., 1993;265:1125 -
Pharmacological, radioligand binding, and electrophysiological characteristics of FPL 64176, a novel nondihydropyridine Ca2+ channel activator, in cardiac and vascular preparations.
Zheng et al.
Mol.Pharmacol., 1991;40:734
Product Datasheets
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Citations for FPL 64176
The citations listed below are publications that use Tocris products. Selected citations for FPL 64176 include:
6 Citations: Showing 1 - 6
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Intracellular emetic signaling evoked by the L-type Ca2+ channel agonist FPL64176 in the least shrew (Cryptotis parva).
Authors: Zhong
Eur J Pharmacol 2018;834:157
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Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.
Authors: Armstrong and Drapeau
Circ Heart Fail 2013;33:1741
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Characterization of Na+ and Ca2+ channels in zebrafish dorsal root ganglion neurons.
Authors: Won Et al.
PLoS One 2012;7:e42602
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Junctophilin-2 expression silencing causes cardiocyte hypertrophy and abnormal intracellular calcium-handling.
Authors: Landstrom Et al.
Endocr Relat Cancer 2011;4:214
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AKAP79/150 signal complexes in G-protein modulation of neuronal ion channels.
Authors: Zhang Et al.
J Neurosci 2011;31:7199
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Ionic currents in intimal cultured synoviocytes from the rabbit.
Authors: Large Et al.
Am J Physiol Cell Physiol 2010;299:C1180
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