(±)-Bay K 8644

Catalog #: 1544
15 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
1544/10
1544/50

(±)-Bay K 8644 | CAS No. 71145-03-4 | Cav1.x Channel Activators

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Description: CaV1.x activator

Chemical Name: 1,4-Dihydro-2,6-dimethyl-5-nitro-4-[2-(trifluoromethyl)phenyl]-3-pyridinecarboxylic acid, methyl ester

Purity: ≥98%

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Product Details

Citations (15)

Reviews

Biological Activity Technical Data Additional Information Background Product Datasheets Calculators

Biological Activity

(±)-Bay K 8644 is a L-type Ca²⁺ channel activator (EC₅₀ = 17.3 nM). Has positive inotropic, vasoconstrictive and behavioral effects in vivo. In combination with BIX-01294 (Cat. No. 3364), helps generate induced pluripotent stem cells (iPSCs) from mouse embryonic fibroblasts (MEFs). Inhibits autophagy.

(S)-(-)-Enantiomer and (R)-(+)-Enantiomer also available.

Technical Data

M.Wt:

356.3

Formula:

C₁₆H₁₅F₃N₂O₄

Solubility:

Soluble to 100 mM in ethanol and to 100 mM in DMSO

Purity:

≥98%

Storage:

Store at +4°C

CAS No:

71145-03-4

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.

Additional Information

Other Product-Specific Information:

Background References

Induction of pluripotent stem cells from mouse embryonic fibroblasts by Oct4 and Klf4 with small-molecule compounds.
Shi et al.
Cell Stem Cell., 2008;3:568
Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies.
Sarkar et al.
Cell Death Differ., 2009;16:46
Calcium channel 'agonist' BAY K 8644 inhibits calcium antagonist binding to brain and PC12 cell membranes.
Greenberg et al.
Brain Res., 1984;305:365
Central and peripheral effects of the dihydropyridine calcium channel activator BAY K 8644 in the rat.
Bourson et al.
Eur.J.Pharmacol., 1989;160:339

Product Datasheets

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*When preparing stock solutions always use the batch-specific molecular weight of the product found on the vial label and CoA (available online).

Citations for (±)-Bay K 8644

The citations listed below are publications that use Tocris products. Selected citations for (±)-Bay K 8644 include:

15 Citations: Showing 1 - 10

An Automated Platform for Assessment of Congenital and Drug-Induced Arrhythmia with hiPSC-Derived Cardiomyocytes.
Authors: McKeithan Et al.
Front Physiol 2017;8:766
Molecular basis of ancestral vertebrate electroreception.
Authors: Bellono
Nature 2017;543:391
Sustained Contraction in Vascular Smooth Muscle by Activation of L-type Ca²⁺ Channels Does Not Involve Ca²⁺ Sensitization or Caldesmon.
Authors: Ets
Front Pharmacol 2016;7:516
Role of Mitochondrial Dynamics in Neuronal Development: Mechanism for Wolfram Syndrome.
Authors: Cagalinec Et al.
PLoS Biol 2016;14:e1002511
Suppression of protective responses upon activation of L-type voltage gated calcium channel in macrophages during mycobacterium bovis BCG infection
Authors: Sharma Et al.
PLoS One 2016;11:e0163845
Estrogen receptor subtypes mediate distinct microvascular dilation and reduction in [Ca2+]I in mesenteric microvessels of female rat.
Authors: Mazzuca Et al.
J Pharmacol Exp Ther 2015;352:291
Dissecting out the complex Ca2+-mediated phenylephrine-induced contractions of mouse aortic segments.
Authors: Fransen Et al.
Circ Heart Fail 2015;10:e0121634
Calcium channel agonists protect against neuromuscular dysfunction in a genetic model of TDP-43 mutation in ALS.
Authors: Armstrong and Drapeau
EMBO J 2013;33:1741
TRPM2 channels are required for NMDA-induced burst firing and contribute to H(2)O(2)-dependent modulation in substantia nigra pars reticulata GABAergic neurons.
Authors: Lee Et al.
J Neurosci 2013;33:1157
The expression and relaxant effect of bitter taste receptors in human bronchi.
Authors: Grassin-Delyle Et al.
Respir Res 2013;14:134

High throughput measurement of Ca²⁺ dynamics for drug risk assessment in human stem cell-derived cardiomyocytes by kinetic image cytometry.
Authors: Cerignoli Et al.
J Pharmacol Toxicol Methods 2012;66:246

A critical role for protein tyrosine phosphatase nonreceptor type 5 in determining individual susceptibility to develop stress-related cognitive and morphological changes.
Authors: Yang Et al.
J Neurosci 2012;32:7550

Activity-dependent phosphorylation of GABAA receptors regulates receptor insertion and tonic current.
Authors: Saliba Et al.
PLoS One 2012;31:2937

Erk1/2 inhibit synaptic vesicle exocytosis through L-type calcium channels.
Authors: Subramanian and Morozov
J Neurosci 2011;31:4755

MEF-2 regulates activity-dependent spine loss in striatopallidal medium spiny neurons.
Authors: Tian Et al.
Mol Cell Neurosci 2010;44:94

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