Human CD38 PE-conjugated Antibody Summary
Met1-Ile300
Accession # P28907
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
Detection of CD38 in Whole Blood Monocytes by Flow Cytometry. Whole blood monocytes were stained with Mouse Anti-Human CD38 PE-conjugated Monoclonal Antibody (Catalog # FAB2404P, filled histogram) or isotype control antibody (Catalog # IC003P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Detection of CD38 in Whole Blood Lymphocytes by Flow Cytometry. Whole blood lymphocytes were stained with Mouse Anti-Human CD38 PE-conjugated Monoclonal Antibody (Catalog # FAB2404P) and Mouse Anti-Human CD3e APC-conjugated Monoclonal Antibody (Catalog # FAB100A). Quadrant markers were set based on control antibody staining. View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
Background: CD38
CD38, also known as ADP-ribosyl cyclase, is a Type II integral membrane protein. The enzyme is able to transform NAD(P)+ into three different products with calcium mobilizing ability, cyclic ADP-ribose, NAADP+, and ADP-ribose (1). CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells (2, 3). Through its production of cyclic ADP-ribose, CD38 modulates calcium-mediated signal transduction in many types of cells, including neutrophils and pancreatic beta cells (4, 5).
- Schuber, F. and F.E. Lund (2004) Curr. Mol. Med. 4:249.
- Jackson, D.G. and J.I. Bell (1990) J. Immunol. 144:2811.
- Sun, L. et al. (1999) J. Cell Biol. 146:1161.
- Partida-Sanchez, S. et al. (2001) Nature Med. 7:1209.
- Kato, I. et al. (1995) J. Biol. Chem. 270:30045.
Product Datasheets
Citations for Human CD38 PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states
Authors: NM Dräger, SM Sattler, CT Huang, OM Teter, K Leng, SH Hashemi, J Hong, G Aviles, CD Clelland, L Zhan, JC Udeochu, L Kodama, AB Singleton, MA Nalls, J Ichida, ME Ward, F Faghri, L Gan, M Kampmann
Nature Neuroscience, 2022-08-11;0(0):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
A Comparative Study of Gene Expression in Menstrual Blood-Derived Stromal Cells between Endometriosis and Healthy Women
Authors: SS Sahraei, F Davoodi As, N Kalhor, M Sheykhhasa, H Fazaeli, SS Moud, A Sheikholes
BioMed Research International, 2022-01-11;2022(0):7053521.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Impact of deranged B cell subsets distribution in the development of HCV-related cirrhosis and HCC in type two diabetes mellitus
Authors: FA Abdelwahab, KM Hassanein, HF Hetta, MO Abdelmalek, AM Zahran, O El-Badawy
Sci Rep, 2020-11-23;10(1):20383.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma.
Authors: Levings PP, McGarry SV, Currie TP, Nickerson DM, McClellan S, Ghivizzani SC, Steindler DA, Gibbs CP
Cancer Res., 2009-07-07;69(14):5648-55.
Species: Mouse
Sample Types: Whole Cells
Applications: Flow Cytometry
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