Human CXCR4 APC-conjugated Antibody

Catalog #: FAB170A
7 Citations Datasheet / COA / SDS

Catalog #	Availability	Size / Price	Qty
FAB170A-025
FAB170A-100

Detection of CXCR4 in Human Blood Lymphocytes by Flow Cytometry.

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All CXCR4 Antibodies

Product Details

Citations (7)

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Summary Data Examples Preparation and Storage Reconstitution Calculator Background Product Datasheets Related Research Areas

Human CXCR4 APC-conjugated Antibody Summary

Species Reactivity

Human

Specificity

Detects human CXCR4.

Source

Monoclonal Mouse IgG_2A Clone # 12G5

Purification

Protein A or G purified from ascites

Immunogen

CP-MAC-infected SUP-T1 human T cell lymphoblastic lymphoma line
Accession # P61073

Formulation

Supplied in a saline solution containing BSA and Sodium Azide.

Label

Allophycocyanin (Excitation= 620-650 nm, Emission= 660-670 nm)

Applications

Recommended Concentration

Sample

Flow Cytometry

10 µL/10⁶ cells

See below

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Scientific Data

Flow Cytometry

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Detection of CXCR4 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CXCR4 APC-conjugated Monoclonal Antibody (Catalog # FAB170A) and Mouse Anti-Human CD19 PE-conjugated Monoclonal Antibody (Catalog # FAB4867P). View our protocol for Staining Membrane-associated Proteins.

Flow Cytometry

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Detection of CXCR4 in Jurkat vs K562 cells by Flow Cytometry Jurkat (filled histogram) vs K562 (open histogram) cells were stained with Mouse Anti-Human CXCR4 APC‑conjugated Monoclonal Antibody (Catalog # FAB170A). View our protocol for Staining Membrane-associated Proteins.

Reconstitution Calculator

Preparation and Storage

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Protect from light. Do not freeze.

12 months from date of receipt, 2 to 8 °C as supplied.

Background: CXCR4

CXCR4, also known as CD184, is a G-protein-linked seven transmembrane spanning receptor that binds stromal cell-derived factor-1 (SDF-1). CXCR4 acts as a co-factor for T-cell tropic HIV-1 and -2 viral entry into cells.

References

Endres, M.J. et al. (1996) Cell 87:745.

Long Name

C-X-C Motif Chemokine Receptor 4

Entrez Gene IDs

7852 (Human); 12767 (Mouse); 60628 (Rat); 483900 (Canine); 493676 (Feline)

Alternate Names

CD184; chemokine (C-X-C motif) receptor 4; chemokine (C-X-C motif), receptor 4 (fusin); C-X-C chemokine receptor type 4; CXCR4; CXC-R4; CXCR-4; D2S201E; D2S201ESDF-1 receptor; FB22; Fusin; HM89; HM89NPYRL; HSY3RR; LAP3; LAP-3; LCR1; LESTR; LESTRCD184 antigen; Leukocyte-derived seven transmembrane domain receptor; leukocyte-derived seven-transmembrane-domain receptor; lipopolysaccharide-associated protein 3; neuropeptide Y receptor Y3; NPY3R; NPY3RWHIM; NPYR; NPYRL; NPYY3R; pCXCR4; seven transmembrane helix receptor; seven-transmembrane-segment receptor, spleen; Stromal cell-derived factor 1 receptor; WHIMS

Product Datasheets

Product Datasheet

COA

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Related Research Areas

Citations for Human CXCR4 APC-conjugated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

7 Citations: Showing 1 - 7
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FOXA2 Is Required for Enhancer Priming during Pancreatic Differentiation
Authors: K Lee, H Cho, RW Rickert, QV Li, J Pulecio, CS Leslie, D Huangfu
Cell Rep, 2019-07-09;28(2):382-393.e7.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Establishment and Characterization of a Pair of Patient-derived Human Non-small Cell Lung Cancer Cell Lines from a Primary Tumor and Corresponding Lymph Node Metastasis
Authors: F Gebauer, D Wicklein, M Tachezy, T Grob, D Steinemann, G Manukjan, G Göhring, B Schlegelbe, H Maar, JR Izbicki, M Bockhorn, U Schumacher
Anticancer Res, 2016-04-01;36(4):1507-18.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
CXCL13 antibody for the treatment of autoimmune disorders.
Authors: Klimatcheva E, Pandina T, Reilly C, Torno S, Bussler H, Scrivens M, Jonason A, Mallow C, Doherty M, Paris M, Smith E, Zauderer M
BMC Immunol, 2015-02-12;16(0):6.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Induction of pluripotency in human somatic cells via a transient state resembling primitive streak-like mesendoderm.
Authors: Takahashi K, Tanabe K, Ohnuki M, Narita M, Sasaki A, Yamamoto M, Nakamura M, Sutou K, Osafune K, Yamanaka S
Nat Commun, 2014-04-24;5(0):3678.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
KDR identifies a conserved human and murine hepatic progenitor and instructs early liver development.
Authors: Goldman O, Han S, Sourisseau M, Dziedzic N, Hamou W, Corneo B, D'Souza S, Sato T, Kotton D, Bissig K, Kalir T, Jacobs A, Evans T, Evans M, Gouon-Evans V
Cell Stem Cell, 2013-06-06;12(6):748-60.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
Chemokine responsiveness of CD4+ CD25+ regulatory and CD4+ CD25- T cells from atopic and nonatopic donors.
Authors: Ahern D, Lloyd CM, Robinson DS
Allergy, 2009-02-07;64(8):1121-9.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
beta -arrestin mediates communication between plasma membrane and intracellular GPCRs to regulate signaling
Authors: Maxwell S. DeNies, Alan V. Smrcka, Santiago Schnell, Allen P. Liu
Communications Biology