Human DLL3 PE-conjugated Antibody Summary
Ala27-Pro488
Accession # Q9NYJ7
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of DLL3 in U‑118‑MG Human Cell Line by Flow Cytometry. U-118-MG human glioblastoma/astrocytoma cell line was stained with Goat Anti-Human DLL3 PE-conjugated Polyclonal Antibody (Catalog # FAB4315P, filled histogram) or isotype control antibody (Catalog # IC108P, open histogram). View our protocol for Staining Membrane-associated Proteins.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: DLL3
DLL3 (Delta-like protein 3; also Delta3) is a 65‑67 kDa member of the Delta family of proteins. It is expressed in/on select cell types in the embryo, including somitic mesoderm, cochlear hair cells and noncycling cells of the neural tube that are undergoing differentiation. DLL3 is principally found in the Golgi apparatus and endosomes where it promotes Notch family receptor degradation. Mature human DLL3 is a 592 amino acid (aa) type I transmembrane protein. It possesses a 466 aa extracellular domain (aa 27-492) that contains a Notch-binding DSL domain (aa 176-215) followed by six EGF-like repeats (aa 216-465). There is one isoform variant that contains an Ala substitution for aa 588-618. Over aa 27-488, human DLL3 shares 84% aa identity with mouse DLL3.
Product Datasheets
Citations for Human DLL3 PE-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 3
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DB-1314, a novel DLL3-targeting ADC with DNA topoisomerase I inhibitor, exhibits promising safety profile and therapeutic efficacy in preclinical small cell lung cancer models
Authors: Lin, S;Zhang, Y;Yao, J;Yang, J;Qiu, Y;Zhu, Z;Hua, H;
Journal of translational medicine
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
SCLC-J1, a novel small cell lung cancer cell line
Authors: K Ohara, S Kinoshita, J Ando, Y Azusawa, M Ishii, S Harada, Y Mitsuishi, T Asao, K Tajima, T Yamamoto, F Takahashi, N Komatsu, K Takahashi, M Ando
Biochemistry and Biophysics Reports, 2021-07-28;27(0):101089.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Generation of Hematopoietic-Like Stem Cells from Adult Human Peripheral Blood Following Treatment with Platelet-Derived Mitochondria
Authors: H Yu, W Hu, X Song, D Descalzi-M, Z Yang, R Korngold, Y Zhao
Int J Mol Sci, 2020-06-15;21(12):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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Detection of DLL3 on CD45- cells from a Non-Small Cell Lung Cancer patient tissue. Single-cell suspension was generated from a lung cancer tissue biopsy and cells were treated a CD45 antibody along with the goat polyclonal Human DLL3 PE-conjugated Antibody (catalog # FAB4315P) (BLUE) or Goat IgG PE-conjugated Antibody (catalog # IC108P) (RED).
