Human GATA-4 Antibody Summary
Met27-Phe211
Accession # P43694
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of Human GATA‑4 by Western Blot. Western blot shows lysates of HepG2 human hepatocellular carcinoma cell line and human liver tissue. PVDF membrane was probed with 0.5 µg/mL of Mouse Anti-Human GATA-4 Monoclonal Antibody (Catalog # MAB2606) followed by HRP-conjugated Anti-Mouse IgG Secondary Antibody (Catalog # HAF007). A specific band was detected for GATA-4 at approximately 56 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1.
Reconstitution Calculator
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: GATA-4
GATA-4 belongs to the GATA family of transcription factors, which bind to the consensus DNA sequence (A/T) GATA (A/G) to control diverse tissue-specific programs of gene expression and morphogenesis. It is widely expressed in mesodermal- and endodermal-derived tissues. GATA-4 interacts with other transcription factors such as NKX2.5, and myocyte enhancer factor 2 to regulate cardiac myocyte-specific gene expression. GATA-4 contains 2 zinc finger-binding domains and migrates at 56 kDa in SDS-PAGE gels. Human GATA-4 share 93%, 93% and 92% amino acid sequence identity with porcine, rat and mouse GATA-4, respectively.
Product Datasheets
Citations for Human GATA-4 Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
7
Citations: Showing 1 - 7
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Transcription factor GATA4 associates with mesenchymal-like gene expression in human hepatoblastoma cells
Authors: Tea Soini, Katja Eloranta, Marjut Pihlajoki, Antti Kyrönlahti, Oyediran Akinrinade, Noora Andersson et al.
Tumour Biol
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In vitro Differentiation of TERT-Transfected Multi-Lineage Progenitor Cells (MLPC) into Immortalized Hepatocyte-Like Cells
Authors: Collins D, Hapke J, Aravalli R, Steer C
HMER
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GATA4 induces liver fibrosis regression by deactivating hepatic stellate cells
Authors: N Arroyo, L Villamayor, I Díaz, R Carmona, M Ramos-Rodr, R Muñoz-Chap, L Pasquali, MG Toscano, F Martin, DA Cano, A Rojas
JCI Insight, 2021-12-08;0(0):.
Species: Mouse
Sample Types: Tissue Lysates
Applications: Western Blot -
Electromechanical Conditioning of Adult Progenitor Cells Improves Recovery of Cardiac Function After Myocardial Infarction
Authors: A Llucià-Val, C Soler-Boti, C Gálvez-Mon, S Roura, C Prat-Vidal, I Perea-Gil, B Sanchez, R Bragos, G Vunjak-Nov, A Bayes-Geni
Stem Cells Transl Med, 2016-09-29;6(3):970-981.
Species: Mouse
Sample Types: Whole Cells, Whole Tissue
Applications: ICC, IHC-Fr -
Hepatic Differentiation of Marmoset Embryonic Stem Cells and Functional Characterization of ESC-Derived Hepatocyte-Like Cells
Authors: Rajagopal N Aravalli, Daniel P Collins, Joel H Hapke, Andrew T Crane, Clifford J Steer
Hepatic Medicine: Evidence and Research
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Induced hepatic stem cells are suitable for human hepatocyte production
Authors: Yoshiki Nakashima, Chika Miyagi-Shiohira, Issei Saitoh, Masami Watanabe, Masayuki Matsushita, Masayoshi Tsukahara et al.
iScience
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The Relationship between the Expression of GATA4 and GATA6 with the Clinical Characteristics and Prognosis of Resectable Pancreatic Adenocarcinoma
Authors: Victoria Heredia-Soto, Laura Gutiérrez-Sainz, Ismael Ghanem, Laura Guerra, Elena Palacios, Marta de Uribe et al.
Biomedicines
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Paraffin-embedded sections
Antigen retrieval: Citrate pH=6
Mouse pancreas
