Cardiac Stem Cell Markers

Cardiac stem cells are thought to be a quiescent, heart-resident population that can reenter the cell cycle following injuries such as acute myocardial infarction. Cardiac stem cells isolated from the myocardium have self-renewal capabilities in vitro and the ability to differentiate in vivo into all three major cardiac cell types: cardiomyocytes, vascular smooth muscle cells, and endothelial cells. In addition, in vivo lineage tracing studies suggest that another population of cardiac progenitor cells expressing TBX18 and WT1 reside in the epicardium. The ability to identify and analyze cardiac stem cells presents researchers with the potential to promote endogenous myocardial regeneration and prevent congestive heart failure.

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