Human IGF-I R/IGF1R Fluorescein-conjugated Antibody Summary
Glu31-Asn932
Accession # P08069
Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of IGF‑I R in MCF‑7 Human Cell Line by Flow Cytometry. MCF-7 human breast cancer cell line was stained with Mouse Anti-Human IGF-I R Fluorescein-conjugated Monoclonal Antibody (Catalog # FAB391F, filled histogram) or isotype control antibody (Catalog # IC002F, open histogram). View our protocol for Staining Membrane-associated Proteins.
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Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: IGF-I R/IGF1R
Insulin-like Growth Factor I Receptor (IGF-I R) is a disulfide-linked heterotetrameric transmembrane protein consisting of two alpha and two beta subunits. Both the alpha and beta subunits are encoded within a single receptor precursor cDNA. The proreceptor polypeptide is proteolytically cleaved and disulfide-linked to yield the mature heterotetrameric receptor. The alpha subunit of IGF-I R is extracellular while the beta subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. IGF-I R is highly expressed in all cell types and tissues. Essentially all of the biological activities of IGF-I and -II have been shown to be mediated via IGF-I R.
Product Datasheets
Citations for Human IGF-I R/IGF1R Fluorescein-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Citations: Showing 1 - 3
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IGFBP6 controls the expansion of chemoresistant glioblastoma through paracrine IGF2/IGF-1R signaling
Authors: Claudia R. Oliva, Brian Halloran, Anita B. Hjelmeland, Ana Vazquez, Shannon M. Bailey, Jann N. Sarkaria et al.
Cell Communication and Signaling
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Insulin-like growth factor 1 receptor and response to anti-IGF1R antibody therapy in osteosarcoma.
Authors: Cao, Yu, Roth, Michael, Piperdi, Sajida, Montoya, Kristofe, Sowers, Rebecca, Rao, Pulivart, Geller, David, Houghton, Peter, Kolb, E Anders, Gill, Jonathan, Gorlick, Richard
PLoS ONE, 2014-08-29;9(8):e106249.
Species: Human
Sample Types: Whole Cells, Whole Tissue
Applications: Flow Cytometry, Flow Cytometry Control -
Growth hormone-induced stimulation of multilineage human hematopoiesis.
Authors: Hanley MB, Napolitano LA, McCune JM
Stem Cells, 2005-06-13;23(8):1170-9.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry
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Human peripheral blood was stained and analyzed by flow cytometry. Monocytes were identified among CD45+ leukocytes and analyzed for IGF-IR expression. This antibody achieves reliable fluorescence in the FITC channel
