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Human IL-19 Biotinylated Antibody

Catalog #: BAF1035
1 Citation Datasheet / COA / SDS
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BAF1035
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Citations (1)
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Human IL-19 Biotinylated Antibody Summary

Species Reactivity
Human
Specificity
Detects human IL-19 in Western blots. In Western blots, no cross-reactivity with recombinant human IL‑10 is observed.
Source
Polyclonal Goat IgG
Purification
Antigen Affinity-purified
Immunogen
E. coli-derived recombinant human IL-19
Leu25-Ala177
Accession # AAN40906
Formulation
Lyophilized from a 0.2 μm filtered solution in PBS with BSA as a carrier protein.
Label
Biotin

Applications

Recommended Concentration
Sample
Western Blot
0.1 µg/mL
Recombinant Human IL‑19 (Catalog # 1035-IL)

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Reconstitution Calculator

Reconstitution Calculator

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial. Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

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Preparation and Storage

Reconstitution
Reconstitute at 0.2 mg/mL in sterile PBS.
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Shipping
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
  • 12 months from date of receipt, -20 to -70 °C as supplied.
  • 1 month, 2 to 8 °C under sterile conditions after reconstitution.
  • 6 months, -20 to -70 °C under sterile conditions after reconstitution.

Background: IL-19

Human Interleukin 19 (IL-19) is a member of the IL-10 family of related cytokines. Its gene contains two alternate translation initiation sites, generating precursors of 215 amino acids (aa) and 177 aa, respectively. Both isoforms are processed to 17 kDa, 153 aa mature molecules. IL-19 contains seven helices and is secreted as a 35 kDa monomer. There are two potential N-linked glycosylation sites, and it is likely that the molecule is glycosylated. Mature human IL-19 shares 69% aa sequence identity with the mature mouse homologue. Although mouse IL-19 is active on human cells, human IL-19 is not active on mouse cells. IL-19 expression is limited to activated keratinocytes and monocytes. IL-19 binds a receptor complex consisting of the IL-20 receptor alpha (IL-20 R alpha, also known as IL-20 R1) and the IL-20 receptor beta (IL-20 R beta or IL-20 R2). This receptor complex is also shared by IL-20 and IL-24. Functionally, IL-19 induces IL-6 and TNF-alpha production by monocytes, and drives T-helper cell differentiation towards a Th2 response (1‑5).

References
  1. Gallagher, G. et al. (2000) Genes Immun. 1:442.
  2. Gallagher, G. et al. (2004) Int. Immunopharmacol. 4:615.
  3. Laio, Y-C. et al. (2002) J. Immunol. 169:4288.
  4. Romer, J. et al. (2003) J. Invest. Dermatol. 121:1306.
  5. Pestka, S. et al. (2004) Annu. Rev. Immunol. 22:929.
Long Name
Interleukin 19
Entrez Gene IDs
29949 (Human); 329244 (Mouse)
Alternate Names
IL-10C; IL19; IL-19; interleukin 19; MDA1; melanoma differentiation associated protein-like protein; NG.1Melanoma differentiation-associated protein-like protein; ZMDA1interleukin-19

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Citation for Human IL-19 Biotinylated Antibody

R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.

1 Citation: Showing 1 - 1

  1. Potentiation of IL-19 expression in airway epithelia by IL-17A and IL-4/IL-13: important implications in asthma.
    Authors: Huang F, Wachi S, Thai P, Loukoianov A, Tan KH, Forteza RM, Wu R
    J. Allergy Clin. Immunol., 2008-06-01;121(6):1415-21, 1421.
    Species: Human
    Sample Types: Cell Culture Supernates
    Applications: ELISA Development

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