Human IL-23R Biotinylated Antibody Summary
Gly24-Ile353
Accession # Q5VWK5
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Preparation and Storage
- 12 months from date of receipt, -20 to -70 °C as supplied.
- 1 month, 2 to 8 °C under sterile conditions after reconstitution.
- 6 months, -20 to -70 °C under sterile conditions after reconstitution.
Background: IL-23R
Interleukin 23 (IL-23) is a heterodimeric cytokine composed of two disulfide-linked subunits, a p19 subunit that is unique to IL-23, and a p40 subunit that is shared with IL-12 (1-5). The functional IL-23 receptor complex consists of two receptor subunits, the IL-12 receptor beta 1 subunit (IL-12 R beta 1) and the IL-23-specific receptor subunit (IL-23 R) (3). Human IL-23 R cDNA encodes a 629 amino acid (aa) type I transmembrane protein with a 23 aa residue signal peptide, a 330 aa residue extracellular domain, a 23 aa residue transmembrane domain, and a 253 aa residue cytoplasmic region. IL-23 R shares structural features with the IL-12 R beta 2, including an N-terminal Ig-like domain, two cytokine receptor domains and multiple glycosylation sites in the extracellular domain. IL-23 R lacks the three extracellular membrane-proximal fibronectin-type III domains present on IL-12 R beta 2. IL-23 R has a WQPWS sequence in the transmembrane-proximal cytokine receptor domain similar to the cytokine receptor signature WSXWS motif. The cytoplasmic region of IL-23 R has three potential Src homology 2 domain-binding sites and two potential STAT-binding sites. The gene for human IL-23 R is located on human chromosome 1 within 150 kb of IL-12 R beta 2. Human and mouse IL-23 R share 66% aa sequence identity. Based on quantitative real-time PCR, human IL-23 R mRNA is expressed in a human Th1 and Th0 clone as well as several NK cell lines and clones. Low but detectable levels of IL-23 R mRNA is also expressed in EBV-transformed B cells and activated PBMC. IL-23 initiates a signal transduction cascade similar to that of IL-12, and involves Jak2, Tyk2, STAT1, STAT3, STAT4, and STAT5. IL-23 has biological activities that are similar to, but distinct from, IL-12.
- Oppmann, B. et al. (2000) Immunity 13:715.
- Lankford, C.S. and D.M. Frucht (2003) J. Leukoc. Biol. 73:49.
- Parham, C. et al. (2002) J. Immunol. 168:5448.
- Belladonna, M.L. et al. (2002) J. Immunol. 168:5448.
- Aggarwal, S. et al. (2003) J. Biol. Chem. 278:1910.
Product Datasheets
Citations for Human IL-23R Biotinylated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
11
Citations: Showing 1 - 10
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The effect of inhaled inactived Mycobacterium phlei as a treatment for asthma
Authors: Moyu Ming, Chaoqian Li, Zhixi Luo, Shengqiu Lv, Qixiang Sun
Molecular Medicine Reports
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Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rbeta1 and subsequent signal transduction
Authors: J Georgy, Y Arlt, JM Moll, M Ouzin, HT Weitz, L Gremer, D Willbold, J Grötzinger, F Thives-Kur, J Scheller, DM Floss
The Journal of Biological Chemistry, 2021-10-09;0(0):101295.
Species: Mouse
Sample Types: Cell Lysates
Applications: Western Blot -
Deciphering site 3 interactions of IL-12 and IL-23 with their cognate murine and human receptors
Authors: A Esch, A Masiarz, S Mossner, JM Moll, J Grötzinger, J Schröder, J Scheller, DM Floss
J. Biol. Chem., 2020-06-09;0(0):.
Species: Mouse
Sample Types: Transduced Whole Cells
Applications: ICC -
Prognostic value of serum soluble interleukin-23 receptor and related T-helper 17 cell cytokines in non-small cell lung carcinoma
Authors: D Liu, S Xing, W Wang, X Huang, H Lin, Y Chen, K Lan, L Chen, F Luo, S Qin, R Liang, C Bai, J Xu, W Liu
Cancer Sci., 2020-03-04;111(4):1093-1102.
Species: Human
Sample Types:
Applications: ELISA (detection) -
The human IL-23 receptor rs11209026 A allele promotes the expression of a soluble IL-23R-encoding mRNA species.
Authors: Yu R, Brazaitis J, Gallagher G
J Immunol, 2014-12-31;194(3):1062-8.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development (Detection) -
The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans.
Authors: Di Meglio P, Di Cesare A, Laggner U
PLoS ONE, 2011-02-22;6(2):e17160.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
A naturally occurring, soluble antagonist of human IL-23 inhibits the development and in vitro function of human Th17 cells.
Authors: Yu RY, Gallagher G
J. Immunol., 2010-11-12;185(12):7302-8.
Species: Human
Sample Types: Cell Culture Supernates
Applications: ELISA Development -
Regulating human Th17 cells via differential expression of IL-1 receptor.
Authors: Lee WW, Kang SW, Choi J
Blood, 2009-11-12;115(3):530-40.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Prostaglandin E2 regulates Th17 cell differentiation and function through cyclic AMP and EP2/EP4 receptor signaling.
Authors: Boniface K, Bak-Jensen KS, Li Y, Blumenschein WM, McGeachy MJ, McClanahan TK, McKenzie BS, Kastelein RA, Cua DJ, de Waal Malefyt R
J. Exp. Med., 2009-03-09;206(3):535-48.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
IL-23 and IL-12 responses in activated human T cells retrovirally transduced with IL-23 receptor variants.
Authors: de Paus RA, van de Wetering D, Van Dissel JT
Mol. Immunol., 2008-09-01;45(15):3889-95.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Induction of the IL-1RII decoy receptor by NFAT/FOXP3 blocks IL-1 beta -dependent response of Th17 cells
Authors: Dong Hyun Kim, Hee Young Kim, Sunjung Cho, Su-Jin Yoo, Won-Ju Kim, Hye Ran Yeon et al.
eLife
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