Human LAIR1 Fluorescein-conjugated Antibody

Applications

Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.

Preparation and Storage

Background: LAIR1

LAIR1 (Leukocyte-associated Ig Like Receptor 1) is an inhibitory receptor belonging to the Ig superfamily. It is a 40 kDa type I transmembrane glycoprotein with one extracellular C2-type Ig-like domain and two cytoplasmic ITIMs. Four LAIR1 splice variants exist. LAIR1b has a 17 aa deletion outside the Ig loop in the extracellular domain. It differs from LAIR1c by one aa residue. LAIR1d has a 77 aa truncation in the cytoplasmic domain. LAIR1 is expressed on NK cells, T cells, B cells, monocytes, dendritic cells and most thymocytes. Consistent with the presence of ITIM motifs,  LAIR1 inhibits IL-2 and IFN-gamma production by CD4⁺ T cells, and reduces IgG and IgE production by B cells. LAIR1 is known to bind to collagens -I, -II, -III, and XVII. The extracellular domain of human LAIR1 shares 40% aa identity with that of the mouse protein.

Product Datasheets

Related Research Areas

• B Cell Activation
• Co-stimulatory and Co-inhibitory Molecules
• Dendritic Cell ITIM/ITAM Immunoreceptors
• ITIM/ITAM Immunoreceptors and Related Molecules
• Monocyte Markers
• T Cell Migration/Adhesion
• Thymocytes