Dendritic Cell ITIM/ITAM Immunoreceptors
ITIMs (immunoreceptor tyrosine-based inhibition motif) and ITAMs (immunoreceptor tyrosine-based activation motif) are phosphorylation motifs found in a large number of receptors or adaptor proteins. Phosphorylated ITIMs recruit tyrosine phosphatases, whereas phosphorylated ITAMs serve as docking sites for tandem SH2 domains of Syk family kinases. Signaling through ITAM-bearing receptors usually results in cell activation, while engagement of ITIM-bearing receptors is usually inhibitory, although exceptions have been described.
- BLAME/SLAMF8
- CD300a/LMIR1
- CD300b/LMIR5
- CD300c2
- CD300d
- CD300e/LMIR6
- CD300f/LMIR3
- CLEC-1
- CLEC4B2/mDCAR1
- CRACC/SLAMF7
- DCAR/CLEC4B
- DCIR/CLEC4A
- DCIR4/CLEC4A1
- Dectin-1/CLEC7A
- Dendritic Cell Differentiation Kits
- Dendritic Cell Flow Cytometry Kits
- Fc gamma RIII (CD16)
- Fc gamma RII/CD32
- Fc gamma RII/RIII (CD32/CD16)
- Fc gamma RIIA/CD32a
- Fc gamma RIIIA/CD16a
- Fc gamma RIIIB/CD16b
- LAIR1
- LILRB1/CD85j/ILT2
- LILRB2/CD85d/ILT4
- LILRB3/CD85a/ILT5
- LILRB4/CD85k/ILT3
- LILRB5/CD85c/LIR-8
- MDL-1/CLEC5A
- PILR-alpha
- Siglec-2/CD22
- Siglec-3/CD33
- Siglec-5/CD170
- Siglec-5/Siglec-14
- Siglec-6/CD327
- Siglec-7/CD328
- Siglec-8
- Siglec-9
- Siglec-10
- Siglec-11
- Siglec-14
- Siglec-E
- Siglec-F
- Siglec-G
- Siglec-H
- SIRP beta 1/CD172b
- SIRP beta 1/gamma
- SIRP beta 1a
- SIRP beta 1B
- SIRP beta 2
- SLAM/CD150
- TREM-3
- TREML1/TLT-1