Human TRAILR4/TNFRSF10D APC-conjugated Antibody Summary
Ala56-His211
Accession # Q9UBN6
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Applications
Please Note: Optimal dilutions should be determined by each laboratory for each application. General Protocols are available in the Technical Information section on our website.
Scientific Data
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Detection of TRAIL R4/TNFRSF10D in Human Blood Granulocytes by Flow Cytometry. Human peripheral blood granulocytes were stained with Mouse Anti-Human TRAIL R4/TNFRSF10D APC‑conjugated Monoclonal Antibody (Catalog # FAB633A, filled histogram) or isotype control antibody (Catalog # IC002A, open histogram). View our protocol for Staining Membrane-associated Proteins.
Preparation and Storage
- 12 months from date of receipt, 2 to 8 °C as supplied.
Background: TRAILR4/TNFRSF10D
Human TRAIL R4, also called Decoy Receptor 2 (DcR2) and TRUNND (TRAIL Receptor with a Truncated Death Domain), is a type I, TNF R family transmembrane protein, which is a receptor for TRAIL (APO2 Ligand). In the TNF superfamily nomenclature, TRAIL R4 is designated as TNFRSF10D. TRAIL R4 is unique among the TRAIL receptors in that its cytoplasmic domain contains a truncated consensus death domain motif. Binding of TRAIL R4 does not result in an apoptotic signal. Overexpression of TRAIL R4 can protect cells bearing TRAIL R1 and/or TRAIL R2 from TRAIL-mediated apoptosis. The human soluble TRAIL R4/Fc chimera neutralizes the ability of TRAIL to induce apoptosis.
- Griffith, T.S. et al. (1998) Curr. Opin. Immunol. 10:559.
- Pan, G. et al. (1998) FEBS lett 424:41.
- Marsters, S.A. et al. (1997) Cur. Biol. 7:1003.
- Degli-Esposti, M.A. et al. (1997) Immunity 7:813.
Product Datasheets
Citations for Human TRAILR4/TNFRSF10D APC-conjugated Antibody
R&D Systems personnel manually curate a database that contains references using R&D Systems products. The data collected includes not only links to publications in PubMed, but also provides information about sample types, species, and experimental conditions.
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Targeting of CD133+ Cancer Stem Cells by Mesenchymal Stem Cell Expressing TRAIL Reveals a Prospective Role of Apoptotic Gene Regulation in Non-Small Cell Lung Cancer
Authors: KS Fakiruddin, MN Lim, N Nordin, R Rosli, Z Zakaria, S Abdullah
Cancers (Basel), 2019-08-28;11(9):.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Impact of p53 status on TRAIL-mediated apoptotic and non-apoptotic signaling in cancer cells
Authors: A Willms, H Schittek, S Rahn, J Sosna, U Mert, D Adam, A Trauzold
PLoS ONE, 2019-04-04;14(4):e0214847.
Species: Human
Sample Types: Whole Cells
Applications: Flow Cytometry -
Impact of Extracellular pH on Apoptotic and Non-Apoptotic TRAIL-Induced Signaling in Pancreatic Ductal Adenocarcinoma Cells
Authors: Sofie Hagelund, Anna Trauzold
Frontiers in Cell and Developmental Biology
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